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Study · Not a test of the peptide alone · 2003

2 results

NANC inhibitory neurotransmission in mouse isolated stomach: involvement of nitric oxide, ATP and vasoactive intestinal polypeptide.

Mulè F, Serio R

British journal of pharmacology11 Aug 2003Cited by 55 (Europe PMC)

PMID12970100 (opens in a new tab)PMCIDPMC1574027 (opens in a new tab)DOI10.1038/sj.bjp.0705431 (opens in a new tab)PepBankPUB-12970100
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  1. 01LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism

    In mouse isolated stomach, relaxation to VIP was abolished by alpha-chymotrypsin and antagonised by VIP6-28, but was not affected by L-NAME, apamin or ADPbetaS.

    In plain wordsIn lab tests on mouse stomach, VIP relaxed the tissue; this was blocked by a VIP blocker and an enzyme, not by other blockers.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableStomach relaxation to VIP and its blockers
    Study

    mousen: not reported in source

    isolated stomach
    Outcome group
    Gastrointestinal motility · Gastrointestinal

    Source sentences

    Summary
    Relaxation to VIP was abolished by alpha-chymotrypsin, antagonised by VIP6-28, but was not affected by l-NAME, apamin or ADPbetaS.
    1 context sentence
    Summary · context
    The neurotransmitters involved in NANC relaxation and their possible interactions were investigated in mouse isolated stomach, recording the motor responses as changes of endoluminal pressure from whole organ.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  2. 02LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism

    In mouse isolated stomach, the VIP receptor antagonist VIP6-28 and alpha-chymotrypsin antagonised the slow relaxation component evoked by field stimulation at 8-32 Hz.

    In plain wordsIn lab tests on mouse stomach, a VIP blocker reduced the slow relaxation caused by nerve stimulation at higher frequencies.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseSlow relaxation to nerve stimulation with VIP antagonist
    Study

    mousen: not reported in source

    isolated stomach
    Comparator
    Without antagonist
    Outcome group
    Gastrointestinal motility · Gastrointestinal

    Source sentences

    Summary
    alpha-Chymotrypsin or vasoactive intestinal polypeptide 6-28 (VIP6-28), antagonist of VIP receptors, failed to affect the fast component or the delayed relaxation to 2-4 Hz, but antagonised the slow component to 8-32 Hz.
    1 context sentence
    Summary · context
    The neurotransmitters involved in NANC relaxation and their possible interactions were investigated in mouse isolated stomach, recording the motor responses as changes of endoluminal pressure from whole organ.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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