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Study · Animal study (in vivo) · rat (lio) · 2003

5 results

Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa.

Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H

International journal of molecular medicine1 Oct 2003Cited by 11 (Europe PMC)

PMID12964022 (opens in a new tab)DOI10.3892/ijmm.12.4.473 (opens in a new tab)PepBankPUB-12964022
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DMH-induced colon tumors, Epitalon attenuated the DMH effect on epithelial proliferation and on stromal and lymphoid areas, most when given throughout the experiment.

    In plain wordsIn rats with colon tumors, Epitalon reduced the tumor-related tissue changes, most when given for the whole experiment.

    Peptide
    Epitalon
    Outcome
    MixedDMH-induced proliferation and stromal and lymphoid areas in colon tumors
    Study

    Rat (LIO)n: not reported in source

    1,2-dimethylhydrazine (DMH) induced colon carcinogenesis
    Comparator
    Saline control
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DMH induced proliferation of the secretory epithelium, and this phenomenon was accompanied by a decrease in the size of the stromal area and the area of lymph infiltration in colon tumors and in the colon mucosa adjacent to the tumors (group 1). Epitalon attenuated this effect, especially when the t…
    1 context sentence
    Summary · context
    Eighty 2-month-old male LIO rats were exposed weekly to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DMH-induced colon tumors, Epitalon increased the stromal areas and the area of lymphoid infiltration in the colon mucosa adjacent to the tumors.

    In plain wordsIn rats with colon tumors, Epitalon enlarged the stromal and immune-cell areas in the tissue next to the tumors.

    Peptide
    Epitalon
    Outcome
    IncreaseStromal area and lymphoid infiltration area in colon mucosa adjacent to tumors
    Study

    Rat (LIO)n: not reported in source

    1,2-dimethylhydrazine (DMH) induced colon carcinogenesis
    Comparator
    Saline control
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It increased the stromal areas, as well as that of lymphoid infiltration in the colon mucosa adjacent to the tumors.
    1 context sentence
    Summary · context
    Eighty 2-month-old male LIO rats were exposed weekly to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DMH-induced colon tumors, Epitalon increased the intensity of lymphoid infiltration in both the colon mucosa adjacent to a tumor and in the tumor.

    In plain wordsIn rats with colon tumors, Epitalon increased immune-cell infiltration in the tumor and the tissue next to it.

    Peptide
    Epitalon
    Outcome
    IncreaseIntensity of lymphoid infiltration in colon mucosa and tumor
    Study

    Rat (LIO)n: not reported in source

    1,2-dimethylhydrazine (DMH) induced colon carcinogenesis
    Comparator
    Saline control
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The intensity of lymphoid infiltration was activated in both the colon mucosa adjacent to a tumor and in the tumor.
    1 context sentence
    Summary · context
    Eighty 2-month-old male LIO rats were exposed weekly to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DMH-induced colon tumors, Epitalon given throughout the experiment significantly inhibited the mitotic activity of tumor cells.

    In plain wordsIn rats with colon tumors, Epitalon given for the whole experiment reduced the division of tumor cells.

    Peptide
    Epitalon
    Outcome
    DecreaseMitotic activity of colon tumor cells
    Study

    Rat (LIO)n: not reported in source

    1,2-dimethylhydrazine (DMH) induced colon carcinogenesis
    Comparator
    Saline control
    Outcome group
    Tumor growth · Cancer
    Studied dose
    1 µg, five times a week · 6 monthsAs given in this study (Rat (LIO)).

    Source sentences

    Summary
    Mitotic activity of tumor cells was significantly inhibited by Epitalon when the treatment was given throughout the experiment (group 2).
    2 context sentences
    Summary · context
    Rats in group 2 were treated with Epitalon at a dose of 1 micro g, five times a week, for 6 months, from the first injection of DMH till the end of the experiment.
    Summary · context
    Eighty 2-month-old male LIO rats were exposed weekly to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DMH-induced colon tumors, a high level of apoptosis was seen in the group given Epitalon throughout the experiment.

    In plain wordsIn rats with colon tumors, Epitalon given for the whole experiment went with a high level of cell death in the tumors.

    Peptide
    Epitalon
    Outcome
    IncreaseApoptosis in colon tumors
    Study

    Rat (LIO)n: not reported in source

    1,2-dimethylhydrazine (DMH) induced colon carcinogenesis
    Comparator
    Saline control
    Outcome group
    Tumor growth · Cancer
    Studied dose
    1 µg, five times a week · 6 monthsAs given in this study (Rat (LIO)).

    Source sentences

    Summary
    In parallel, a high level of apoptosis was seen in the same group.
    2 context sentences
    Summary · context
    Rats in group 2 were treated with Epitalon at a dose of 1 micro g, five times a week, for 6 months, from the first injection of DMH till the end of the experiment.
    Summary · context
    Eighty 2-month-old male LIO rats were exposed weekly to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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