Melanocortin receptors mediate leptin effects on feeding and body weight but not adipose apoptosis.

Choi YH, Li C, Page K, Westby A, Della-Fera MA, Lin J, Hartzell DL, Baile CA

Physiology & behavior1 Sept 2003Cited by 23 (Europe PMC)

PMID12954425DOI10.1016/s0031-9384(03)00205-1PepBankPUB-12954425

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In male rats, intracerebroventricular melanotan II decreased food intake, and the MC3/4 receptor antagonist SHU9119 completely prevented this decrease.
In plain wordsIn rats, melanotan II injected into the brain reduced food intake, and a receptor blocker prevented this.
Peptide
Melanotan II
Outcome
DecreaseFood intake
Study
ratn: not reported in source
Comparator
aCSF
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
0.1 nmol/5 microl · intracerebroventricular · 4 daysAs given in this study (rat).
Source sentences
Summary
SHU9119 completely prevented the decrease in FI and BW caused by either MTII or leptin.
1 context sentence(design, population, supporting numbers)
Summary · context
To test this hypothesis, male Sprague-Dawley rats received pretreatments of intracerebroventricular injections of artificial cerebrospinal fluid (aCSF, 5 microl) or SHU9119 (1.0 nmol/5 microl), an MC3/4 receptor antagonist.
Report a problemFND-1295442501
02AnimalAnimal study (in vivo)Efficacy outcome
In male rats, intracerebroventricular melanotan II decreased body weight, and SHU9119 completely prevented this decrease.
In plain wordsIn rats, melanotan II injected into the brain lowered body weight, and a receptor blocker prevented this.
Peptide
Melanotan II
Outcome
DecreaseBody weight
Study
ratn: not reported in source
Comparator
aCSF
Outcome group
Body weight · Metabolic and weight
Studied dose
0.1 nmol/5 microl · intracerebroventricular · 4 daysAs given in this study (rat).
Source sentences
Summary
SHU9119 completely prevented the decrease in FI and BW caused by either MTII or leptin.
1 context sentence(design, population, supporting numbers)
Summary · context
To test this hypothesis, male Sprague-Dawley rats received pretreatments of intracerebroventricular injections of artificial cerebrospinal fluid (aCSF, 5 microl) or SHU9119 (1.0 nmol/5 microl), an MC3/4 receptor antagonist.
Report a problemFND-1295442502
03AnimalAnimal study (in vivo)Efficacy outcome
In male rats, melanotan II significantly reduced the mass of inguinal, retroperitoneal and epididymal white adipose tissue.
In plain wordsIn rats, melanotan II reduced the weight of three white fat deposits.
Peptide
Melanotan II
Outcome
DecreaseWhite adipose tissue mass (iWAT, rWAT, eWAT)
Study
ratn: not reported in source
Comparator
aCSF
Outcome group
Body composition · Metabolic and weight
Studied dose
0.1 nmol/5 microl · intracerebroventricular · 4 daysAs given in this study (rat).
Source sentences
Summary
but both leptin and MTII significantly reduced mass of inguinal (iWAT), retroperitoneal (rWAT), and epididymal (eWAT) white adipose tissues (P<.05).
1 context sentence(design, population, supporting numbers)
Summary · context
To test this hypothesis, male Sprague-Dawley rats received pretreatments of intracerebroventricular injections of artificial cerebrospinal fluid (aCSF, 5 microl) or SHU9119 (1.0 nmol/5 microl), an MC3/4 receptor antagonist.
Report a problemFND-1295442503
04AnimalAnimal study (in vivo)Efficacy outcome
In male rats, muscle mass did not change with melanotan II or any other treatment.
In plain wordsIn rats, melanotan II did not change muscle mass.
Peptide
Melanotan II
Outcome
No significant changeMuscle mass
Study
ratn: not reported in source
Comparator
aCSF
Outcome group
Body weight · Metabolic and weight
Studied dose
0.1 nmol/5 microl · intracerebroventricular · 4 daysAs given in this study (rat).
Source sentences
Summary
Muscle mass remained unchanged regardless of treatment
1 context sentence(design, population, supporting numbers)
Summary · context
To test this hypothesis, male Sprague-Dawley rats received pretreatments of intracerebroventricular injections of artificial cerebrospinal fluid (aCSF, 5 microl) or SHU9119 (1.0 nmol/5 microl), an MC3/4 receptor antagonist.
Report a problemFND-1295442504
05AnimalAnimal study (in vivo)Mechanism
In male rats, melanotan II did not increase DNA fragmentation in epididymal white adipose tissue, unlike leptin.
In plain wordsIn rats, melanotan II did not increase fat cell death, while leptin did.
Peptide
Melanotan II
Outcome
No significant changeDNA fragmentation (apoptosis) in epididymal white adipose tissue
Study
ratn: not reported in source
Comparator
aCSF
Outcome group
Body composition · Metabolic and weight
Studied dose
0.1 nmol/5 microl · intracerebroventricular · 4 daysAs given in this study (rat).
Source sentences
Summary
Leptin, but not MTII, increased DNA fragmentation in eWAT (P<.05)
1 context sentence(design, population, supporting numbers)
Summary · context
To test this hypothesis, male Sprague-Dawley rats received pretreatments of intracerebroventricular injections of artificial cerebrospinal fluid (aCSF, 5 microl) or SHU9119 (1.0 nmol/5 microl), an MC3/4 receptor antagonist.
Report a problemFND-1295442505

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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