In female prairie voles, a single neonatal treatment with an oxytocin antagonist was associated with fewer ultrasonic vocalizations during social isolation.
In plain wordsIn female prairie voles, a drug that blocks oxytocin, given once as newborns, was linked to fewer distress calls later.
- Peptide
- Oxytocin
- Outcome
- DecreaseUltrasonic vocalizations after single neonatal OTA treatment
- Study
prairie vole (Microtus ochrogaster)n: not reported in source
neonatal prairie voles, females- Outcome group
- Anxiety and mood · Mental health and mood
Source sentences
A single treatment with OTA was associated with a decrease in vocalizations
2 context sentences(design, population, supporting numbers)
We investigated the effects of neonatal exposure to OT on the development of the stress response in male and female prairie voles (Microtus ochrogaster).
OT or an OT antagonist (OTA) was administered either on postnatal day 1 (single, D1) or days 1-7 (repeated, D1-7) and then on day 8 the response to social isolation was assessed by quantifying ultrasonic vocalizations (USVs) and measuring plasma corticosterone (CORT).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.