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Study · Measured the body's own peptide · 2004

1 result

Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin.

Wigger A, Sánchez MM, Mathys KC, Ebner K, Frank E, Liu D, Kresse A, Neumann ID, Holsboer F, Plotsky PM, Landgraf R

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology1 Jan 2004Cited by 182 (Europe PMC)

PMID12942143 (opens in a new tab)DOI10.1038/sj.npp.1300290 (opens in a new tab)PepBankPUB-12942143
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In rats bred for high anxiety, the body's own oxytocin mRNA expression in the paraventricular nucleus did not differ from that in rats bred for low anxiety.

    In plain wordsIn rats bred for high anxiety, the body's own oxytocin gene activity in one brain area was not higher than in low-anxiety rats.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin mRNA expression in the paraventricular nucleus
    Study

    ratn: not reported in source

    Comparator
    Low-anxiety (LAB) rats
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    AVP, but not OXT, mRNA expression as well as release of the neuropeptide, were higher in the PVN of HABs
    2 context sentences
    Summary · context
    To model aspects of trait anxiety/depression, Wistar rats were bred for extremes in either hyper (HAB)- or hypo(LAB)-anxiety as measured on the elevated plus-maze and in a variety of additional behavioral tests.
    Summary · context
    Thus, CRH, arginine-8-vasopressin (AVP), and oxytocin (OXT) were studied in brains of HAB and LAB males both under basal conditions and after exposure to a mild emotional stressor.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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