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Study · Ex vivo tissue · 2003

3 results

Cyclopropyl glycine and proline-containing preparation noopept evoke two types of membrane potential responses in synaptoneurosomes.

Lutsenko VK, Vukolova MN, Gudasheva TA

Bulletin of experimental biology and medicine1 Jun 2003Cited by 1 (Europe PMC)

PMID12937673 (opens in a new tab)DOI10.1023/a:1025425218023 (opens in a new tab)PepBankPUB-12937673
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In synaptoneurosomes, GVS-111 decreased membrane potential in calcium-free medium.

    In plain wordsIn lab tests, GVS-111 decreased membrane potential without calcium.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseMembrane potential without calcium
    Study

    n: not reported in source

    synaptoneurosomes
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Proline, cyclo(Pro-Gly), and acyl-prolyl-containing dipeptide GVS-111 decreased synaptoneurosome membrane potential in a Ca2+-free medium.
  2. 02LabEx vivo tissueMechanism

    In synaptoneurosomes, GVS-111 had greater depolarizing efficiency than cyclo(Pro-Gly) and proline.

    In plain wordsIn lab tests, GVS-111 reduced membrane potential more efficiently than cyclo(Pro-Gly) and proline.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseRelative depolarizing efficiency
    Study

    n: not reported in source

    synaptoneurosomes
    Comparator
    cyclo(Pro-Gly) and proline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The efficiency of these preparations decreased in the following order: GVS>cyclo(Pro-Gly)>proline.
    1 context sentence
    Summary · context
    Proline, cyclo(Pro-Gly), and acyl-prolyl-containing dipeptide GVS-111 decreased synaptoneurosome membrane potential in a Ca2+-free medium.
  3. 03LabEx vivo tissueMechanism

    In synaptoneurosomes, GVS induced both hyperpolarizing and depolarizing responses in calcium-containing medium.

    In plain wordsIn lab tests, GVS caused both increases and decreases in membrane potential with calcium.

    Peptide
    Noopept (omberacetam)
    Outcome
    MixedMembrane responses with calcium
    Study

    n: not reported in source

    synaptoneurosomes
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a Ca2+-containing medium GVS and cyclo(Pro-Gly) induced both hyperpolarizing and depolarizing membrane responses of synaptoneurosomes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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