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Study · Measured the body's own peptide · 2003

2 results

Increased expression of vasoactive intestinal polypeptide in cultured myenteric neurons from adult rat small intestine.

Lin Z, Sandgren K, Ekblad E

Autonomic neuroscience : basic & clinical1 Aug 2003Cited by 36 (Europe PMC)

PMID12927222 (opens in a new tab)DOI10.1016/s1566-0702(03)00077-8 (opens in a new tab)PepBankPUB-12927222
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Other

    In cultured myenteric neurons from adult rat small intestine, the relative number of VIP-expressing neurons increased significantly during culture, from 3.6% in whole mounts to 22-24% in ganglia and up to 35% in dissociated neurons.

    In plain wordsIn cultured rat gut neurons, more neurons made the body's own VIP than in intact tissue.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP-expressing myenteric neurons
    Study

    ratn: not reported in source

    cultured myenteric neurons
    Comparator
    Whole-mount preparations
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Measurements

    VIP-expressing neurons
    3.6%
    whole mounts
    VIP-expressing neurons
    22 to 24%
    cultured ganglia
    VIP-expressing neurons
    ≤ 35%
    dissociated neurons

    Source sentences

    Summary
    The relative number of VIP-expressing neurons increased significantly during culturing. The percentage of all neurons expressing VIP was 3.6+/-0.3% in whole mounts, 22-24% in cultured myenteric ganglia, and up to 35% in cultured dissociated neurons.
    1 context sentence
    Summary · context
    Myenteric ganglia and neurons from rat small intestine were dissociated and cultured for up to 21 days.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Other

    In cultured myenteric neurons from adult rat small intestine, the number of neurons containing both NOS and VIP increased dramatically compared with whole mounts.

    In plain wordsIn cultured rat gut neurons, many more neurons held both NOS and the body's own VIP than in intact tissue.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseNOS/VIP-containing neurons
    Study

    ratn: not reported in source

    cultured myenteric neurons
    Comparator
    Whole-mount preparations
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    A dramatic increase in NOS/VIP-containing neurons were detected in cultured neurons irrespective of whether they were arranged in ganglia or dissociated, as compared to whole mount preparations.
    1 context sentence
    Summary · context
    Myenteric ganglia and neurons from rat small intestine were dissociated and cultured for up to 21 days.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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