Positive effects of cerebrolysin on electroencephalogram slowing, cognition and clinical outcome in patients with postacute traumatic brain injury: an exploratory study.

Alvarez XA, Sampedro C, Pérez P, Laredo M, Couceiro V, Hernández A, Figueroa J, Varela M, Arias D, Corzo L, Zas R, Lombardi V and 6 more

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Fernández-Novoa L, Pichel V, Cacabelos R, Windisch M, Aleixandre M, Moessler H

International clinical psychopharmacology1 Sept 2003Cited by 29 (Europe PMC)

PMID12920387DOI10.1097/00004850-200309000-00003PepBankPUB-12920387

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanNon-randomized trialEfficacy outcome
In postacute traumatic brain injury patients, Cerebrolysin decreased slow EEG activity after administration.
In plain wordsIn patients after traumatic brain injury, slow brain electrical activity decreased after Cerebrolysin.
Peptide
Cerebrolysin
Outcome
DecreaseSlow EEG activity
Study
n: not reported in source
Analysis
Exploratory
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A decrease in slow electroencephalogram (EEG) activity and an increase in fast frequencies were observed after the administration of Cerebrolysin.
1 context sentence(design, population, supporting numbers)
Summary · context
The potential effects of Cerebrolysin (EBEWE Pharma, Unterach, Austria), a peptide preparation with neurotrophic activity, on brain bioelectrical activity, cognitive performance and clinical outcome in postacute traumatic brain injury (TBI) patients, were investigated in an exploratory study.
Report a problemFND-1292038701
02HumanNon-randomized trialEfficacy outcome
In postacute traumatic brain injury patients, Cerebrolysin increased fast EEG frequencies after administration.
In plain wordsIn patients after traumatic brain injury, fast brain electrical frequencies increased after Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseFast EEG frequencies
Study
n: not reported in source
Analysis
Exploratory
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
A decrease in slow electroencephalogram (EEG) activity and an increase in fast frequencies were observed after the administration of Cerebrolysin.
1 context sentence(design, population, supporting numbers)
Summary · context
The potential effects of Cerebrolysin (EBEWE Pharma, Unterach, Austria), a peptide preparation with neurotrophic activity, on brain bioelectrical activity, cognitive performance and clinical outcome in postacute traumatic brain injury (TBI) patients, were investigated in an exploratory study.
Report a problemFND-1292038702
03HumanNon-randomized trialEfficacy outcome
In traumatic brain injury patients, Cerebrolysin-related EEG activation did not depend on injury course, severity, or chronic nootropic treatment.
In plain wordsIn brain injury patients, Cerebrolysin-related brain electrical activation did not depend on injury course, severity, or chronic nootropic treatment.
Peptide
Cerebrolysin
Outcome
No significant changeEEG activation modifiers
Study
n: not reported in source
Analysis
Exploratory
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
This EEG-activating effect was not influenced by TBI time course or severity, nor by the chronic treatment with nootropic compounds.
1 context sentence(design, population, supporting numbers)
Summary · context
The potential effects of Cerebrolysin (EBEWE Pharma, Unterach, Austria), a peptide preparation with neurotrophic activity, on brain bioelectrical activity, cognitive performance and clinical outcome in postacute traumatic brain injury (TBI) patients, were investigated in an exploratory study.
Report a problemFND-1292038703
04HumanNon-randomized trialEfficacy outcome
In traumatic brain injury patients, cognitive performance improved after Cerebrolysin independently of severity, time course, or disability.
In plain wordsIn brain injury patients, thinking performance improved after Cerebrolysin regardless of injury severity, time course, or disability.
Peptide
Cerebrolysin
Outcome
IncreaseCognitive performance
Study
n: not reported in source
Analysis
Exploratory
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Cognitive performance, evaluated with the Syndrome Kurztest test, improved in TBI patients after Cerebrolysin treatment, independent of disease severity, time course or disability.
1 context sentence(design, population, supporting numbers)
Summary · context
The potential effects of Cerebrolysin (EBEWE Pharma, Unterach, Austria), a peptide preparation with neurotrophic activity, on brain bioelectrical activity, cognitive performance and clinical outcome in postacute traumatic brain injury (TBI) patients, were investigated in an exploratory study.
Report a problemFND-1292038704
05HumanNon-randomized trialEfficacy outcome
In traumatic brain injury patients, clinical outcome improved after Cerebrolysin infusions only during the first year after trauma.
In plain wordsIn brain injury patients, clinical outcome improved after Cerebrolysin only during the first year after injury.
Peptide
Cerebrolysin
Outcome
IncreaseClinical outcome
Study
n: not reported in source
Analysis
Exploratory
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · infusionAs given in this study (human).
Source sentences
Summary
A significant improvement in the patients' clinical outcome, only evident during the first year after brain trauma, was also found following Cerebrolysin infusions.
1 context sentence(design, population, supporting numbers)
Summary · context
The potential effects of Cerebrolysin (EBEWE Pharma, Unterach, Austria), a peptide preparation with neurotrophic activity, on brain bioelectrical activity, cognitive performance and clinical outcome in postacute traumatic brain injury (TBI) patients, were investigated in an exploratory study.
Report a problemFND-1292038705
06HumanNon-randomized trialSafety outcome
In postacute traumatic brain injury patients, no relevant biological parameter changes occurred after Cerebrolysin.
In plain wordsIn brain injury patients, no relevant changes in biological measurements occurred after Cerebrolysin.
Peptide
Cerebrolysin
Outcome
No significant changeBiological parameters
Study
n: not reported in source
Analysis
Exploratory
Outcome group
Adverse events · Whole body
Studied dose
Dose not stated
Source sentences
Summary
No relevant changes in biological parameters nor drug-related adverse events were observed.
1 context sentence(design, population, supporting numbers)
Summary · context
The potential effects of Cerebrolysin (EBEWE Pharma, Unterach, Austria), a peptide preparation with neurotrophic activity, on brain bioelectrical activity, cognitive performance and clinical outcome in postacute traumatic brain injury (TBI) patients, were investigated in an exploratory study.
Report a problemFND-1292038706
07HumanNon-randomized trialSafety outcome
In postacute traumatic brain injury patients, no drug-related adverse events occurred with Cerebrolysin.
In plain wordsIn brain injury patients, no drug-related adverse events occurred with Cerebrolysin.
Peptide
Cerebrolysin
Outcome
Direction not reportedDrug-related adverse events
Study
n: not reported in source
Analysis
Exploratory
Outcome group
Adverse events · Whole body
Studied dose
Dose not stated
Source sentences
Summary
No relevant changes in biological parameters nor drug-related adverse events were observed.
1 context sentence(design, population, supporting numbers)
Summary · context
The potential effects of Cerebrolysin (EBEWE Pharma, Unterach, Austria), a peptide preparation with neurotrophic activity, on brain bioelectrical activity, cognitive performance and clinical outcome in postacute traumatic brain injury (TBI) patients, were investigated in an exploratory study.
Report a problemFND-1292038707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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