Effects of combined treatment of insulin and human parathyroid hormone(1-34) on cancellous bone mass and structure in streptozotocin-induced diabetic rats.

Suzuki K, Miyakoshi N, Tsuchida T, Kasukawa Y, Sato K, Itoi E

Bone1 Jul 2003Cited by 50 (Europe PMC)

PMID12919705DOI10.1016/s8756-3282(03)00169-8PepBankPUB-12919705

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, hPTH alone improved cancellous bone volume compared with baseline controls.
In plain wordsIn rats with diabetes, hPTH alone improved cancellous bone volume compared with baseline controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous bone volume
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Baseline controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 4 weeksAs given in this study (rat).
Source sentences
Summary
The decreased cancellous bone volume (BV/TV) and bone formation in diabetic rats improved in all the drug-treated groups compared with baseline controls.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
Report a problemFND-1291970501
02AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, hPTH alone improved bone formation compared with baseline controls.
In plain wordsIn rats with diabetes, hPTH alone improved bone formation compared with baseline controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone formation
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Baseline controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 4 weeksAs given in this study (rat).
Source sentences
Summary
The decreased cancellous bone volume (BV/TV) and bone formation in diabetic rats improved in all the drug-treated groups compared with baseline controls.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
Report a problemFND-1291970502
03AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, insulin plus hPTH produced greater bone volume recovery than insulin alone.
In plain wordsIn rats with diabetes, insulin plus hPTH improved bone volume more than insulin alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous bone volume
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Insulin alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 4 weeksAs given in this study (rat).
Source sentences
Summary
Furthermore, recovery of BV/TV was greater in rats that received the combination of insulin and hPTH than in those that received insulin or hPTH alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
Report a problemFND-1291970503
04AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, hPTH alone did not increase the trabecular node-related parameter.
In plain wordsIn rats with diabetes, hPTH alone did not increase the trabecular node-related parameter.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeTrabecular node-related parameter
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 4 weeksAs given in this study (rat).
Source sentences
Summary
In node-strut analysis, the node-related parameter (N.Nd/TV) significantly increased in rats that received the combination of insulin and hPTH, but did not increase in those that received insulin or hPTH alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
Report a problemFND-1291970505
05AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, insulin plus hPTH increased femoral bone mineral density more than insulin alone.
In plain wordsIn rats with diabetes, insulin plus hPTH increased femoral bone density more than insulin alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFemoral bone mineral density
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Insulin alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 4 weeksAs given in this study (rat).
Source sentences
Summary
In addition to these results, the combination treatment significantly increased bone mineral density of the femur and bone strength in the femoral metaphysis compared with treatment with insulin or hPTH alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
Report a problemFND-1291970507
06AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, insulin plus hPTH increased femoral metaphyseal strength more than insulin alone.
In plain wordsIn rats with diabetes, insulin plus hPTH increased femoral strength more than insulin alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFemoral metaphyseal strength
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Insulin alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 4 weeksAs given in this study (rat).
Source sentences
Summary
In addition to these results, the combination treatment significantly increased bone mineral density of the femur and bone strength in the femoral metaphysis compared with treatment with insulin or hPTH alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
Report a problemFND-1291970509

Studies that did not test the peptide alone6

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

07AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, insulin plus hPTH produced greater bone volume recovery than hPTH alone.
In plain wordsIn rats with diabetes, insulin plus hPTH improved bone volume more than hPTH alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous bone volume
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
hPTH alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Furthermore, recovery of BV/TV was greater in rats that received the combination of insulin and hPTH than in those that received insulin or hPTH alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1291970504
08AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, insulin plus hPTH significantly increased the trabecular node-related parameter.
In plain wordsIn rats with diabetes, insulin plus hPTH increased the trabecular node-related parameter.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTrabecular node-related parameter
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In node-strut analysis, the node-related parameter (N.Nd/TV) significantly increased in rats that received the combination of insulin and hPTH, but did not increase in those that received insulin or hPTH alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1291970506
09AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, insulin plus hPTH increased femoral bone mineral density more than hPTH alone.
In plain wordsIn rats with diabetes, insulin plus hPTH increased femoral bone density more than hPTH alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFemoral bone mineral density
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
hPTH alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In addition to these results, the combination treatment significantly increased bone mineral density of the femur and bone strength in the femoral metaphysis compared with treatment with insulin or hPTH alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1291970508
10AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, insulin plus hPTH increased femoral metaphyseal strength more than hPTH alone.
In plain wordsIn rats with diabetes, insulin plus hPTH increased femoral strength more than hPTH alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFemoral metaphyseal strength
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
hPTH alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In addition to these results, the combination treatment significantly increased bone mineral density of the femur and bone strength in the femoral metaphysis compared with treatment with insulin or hPTH alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1291970510
11AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, insulin plus hPTH improved cancellous bone volume compared with baseline controls.
In plain wordsIn rats with diabetes, insulin plus hPTH improved cancellous bone volume compared with baseline controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCancellous bone volume
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Baseline controls
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The decreased cancellous bone volume (BV/TV) and bone formation in diabetic rats improved in all the drug-treated groups compared with baseline controls.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1291970511
12AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, insulin plus hPTH improved bone formation compared with baseline controls.
In plain wordsIn rats with diabetes, insulin plus hPTH improved bone formation compared with baseline controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone formation
Study
ratn: not reported in source
Streptozotocin-induced diabetes
Comparator
Baseline controls
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The decreased cancellous bone volume (BV/TV) and bone formation in diabetic rats improved in all the drug-treated groups compared with baseline controls.
1 context sentence(design, population, supporting numbers)
Summary · context
Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) in 7-month-old female Wistar rats. The diabetic rats received insulin, hPTH, insulin and hPTH, or hPTH vehicle for 4 weeks, starting 8 weeks after STZ injection.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1291970512

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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