Pharmacogenetic study of anxiolytic effects of new cholecystokinin receptor antagonists in animals with different levels of emotionality.

Kolik LG, Gudasheva TA, Seredenin SB

Bulletin of experimental biology and medicine1 May 2003Cited by 4 (Europe PMC)

PMID12910281DOI10.1023/a:1024907207370PepBankPUB-12910281

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Balb/c mice, GB‑115 dose-dependently increased total locomotor activity in the open-field test.
In plain wordsIn mice of the Balb/c strain, GB‑115 increased movement in the open-field test as doses increased.
Peptide
GB-115
Outcome
IncreaseOpen-field total locomotor activity
Study
mousen: not reported in source
Balb/c mice
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.006-0.100 mg/kgAs given in this study (mouse).
Source sentences
Summary
The test drugs dose-dependently increased the total locomotor activity in the open field test in Balb/c mice and had no effect on the behavior of C57Bl/6 mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of two new peptide antagonists of central cholecystokinin receptors, GB-101 (0.05-0.40 mg/kg) and GB-115 (0.006-0.100 mg/kg), on the behavior of inbred animals differing by the reactions to emotional stress were studied in standard tests for evaluation of tranquilizers.
Report a problemFND-1291028101
02AnimalAnimal study (in vivo)Efficacy outcome
In C57Bl/6 mice, GB‑115 had no effect on behavior in the open-field test.
In plain wordsIn mice of the C57Bl/6 strain, GB‑115 did not change behavior in the open-field test.
Peptide
GB-115
Outcome
No significant changeOpen-field behavior
Study
mousen: not reported in source
C57Bl/6 mice
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.006-0.100 mg/kgAs given in this study (mouse).
Source sentences
Summary
The test drugs dose-dependently increased the total locomotor activity in the open field test in Balb/c mice and had no effect on the behavior of C57Bl/6 mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of two new peptide antagonists of central cholecystokinin receptors, GB-101 (0.05-0.40 mg/kg) and GB-115 (0.006-0.100 mg/kg), on the behavior of inbred animals differing by the reactions to emotional stress were studied in standard tests for evaluation of tranquilizers.
Report a problemFND-1291028102
03AnimalAnimal study (in vivo)Efficacy outcome
In MR rats, GB‑115 produced an anxiolytic effect in the elevated plus-maze test.
In plain wordsIn MR rats, GB‑115 reduced anxiety-related behavior in the elevated plus-maze test.
Peptide
GB-115
Outcome
DecreaseElevated plus-maze anxiety
Study
ratn: not reported in source
MR rats
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.025 and 0.05 mg/kgAs given in this study (rat).
Source sentences
Summary
GB-101 (0.4 mg/kg) and GB-115 (0.025 and 0.05 mg/kg) produced an anxiolytic effect on MR rats (but not on MNRA rats) in the elevated plus-maze and conflict tests.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of two new peptide antagonists of central cholecystokinin receptors, GB-101 (0.05-0.40 mg/kg) and GB-115 (0.006-0.100 mg/kg), on the behavior of inbred animals differing by the reactions to emotional stress were studied in standard tests for evaluation of tranquilizers.
Report a problemFND-1291028103
04AnimalAnimal study (in vivo)Efficacy outcome
In MR rats, GB‑115 produced an anxiolytic effect in the conflict test.
In plain wordsIn MR rats, GB‑115 reduced anxiety-related behavior in the conflict test.
Peptide
GB-115
Outcome
DecreaseConflict-test anxiety
Study
ratn: not reported in source
MR rats
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.025 and 0.05 mg/kgAs given in this study (rat).
Source sentences
Summary
GB-101 (0.4 mg/kg) and GB-115 (0.025 and 0.05 mg/kg) produced an anxiolytic effect on MR rats (but not on MNRA rats) in the elevated plus-maze and conflict tests.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of two new peptide antagonists of central cholecystokinin receptors, GB-101 (0.05-0.40 mg/kg) and GB-115 (0.006-0.100 mg/kg), on the behavior of inbred animals differing by the reactions to emotional stress were studied in standard tests for evaluation of tranquilizers.
Report a problemFND-1291028104
05AnimalAnimal study (in vivo)Efficacy outcome
In MNRA rats, GB‑115 did not produce an anxiolytic effect in the elevated plus-maze test.
In plain wordsIn MNRA rats, GB‑115 did not reduce anxiety-related behavior in the elevated plus-maze test.
Peptide
GB-115
Outcome
No significant changeElevated plus-maze anxiety
Study
ratn: not reported in source
MNRA rats
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.025 and 0.05 mg/kgAs given in this study (rat).
Source sentences
Summary
GB-101 (0.4 mg/kg) and GB-115 (0.025 and 0.05 mg/kg) produced an anxiolytic effect on MR rats (but not on MNRA rats) in the elevated plus-maze and conflict tests.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of two new peptide antagonists of central cholecystokinin receptors, GB-101 (0.05-0.40 mg/kg) and GB-115 (0.006-0.100 mg/kg), on the behavior of inbred animals differing by the reactions to emotional stress were studied in standard tests for evaluation of tranquilizers.
Report a problemFND-1291028105
06AnimalAnimal study (in vivo)Efficacy outcome
In MNRA rats, GB‑115 did not produce an anxiolytic effect in the conflict test.
In plain wordsIn MNRA rats, GB‑115 did not reduce anxiety-related behavior in the conflict test.
Peptide
GB-115
Outcome
No significant changeConflict-test anxiety
Study
ratn: not reported in source
MNRA rats
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.025 and 0.05 mg/kgAs given in this study (rat).
Source sentences
Summary
GB-101 (0.4 mg/kg) and GB-115 (0.025 and 0.05 mg/kg) produced an anxiolytic effect on MR rats (but not on MNRA rats) in the elevated plus-maze and conflict tests.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of two new peptide antagonists of central cholecystokinin receptors, GB-101 (0.05-0.40 mg/kg) and GB-115 (0.006-0.100 mg/kg), on the behavior of inbred animals differing by the reactions to emotional stress were studied in standard tests for evaluation of tranquilizers.
Report a problemFND-1291028106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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