In rats, MT II dose-dependently and significantly reduced the number of licking periods in the Vogel conflict test, which suggests anxiogenic-like activity.
In plain wordsIn rats, MT II lowered licking in a conflict test, which points to anxiety-like behaviour.
- Peptide
- Melanotan II
- Outcome
- DecreaseLicking periods in the Vogel conflict test
- Study
ratn: not reported in source
- Outcome group
- Anxiety and mood · Mental health and mood
- Studied dose
- Dose not stated
Source sentences
the melanocortin MC4 receptor agonist, Ac-[Nle4,Asp5,D-Phe7,Lys10]alpha-MSH-(4-10)-NH2 (MT II) dose-dependently and significantly reduced the number of licking periods in the rat Vogel conflict test, suggesting that stimulation of the melanocortin MC4 receptor causes anxiogenic-like activity in rats.
1 context sentence(design, population, supporting numbers)
We made use of melanocortin MC4 receptor agonists and antagonist to investigate the relationship between the melanocortin MC4 receptor and stress related disorders.