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Study · Animal study (in vivo) · mouse · 2003

6 results

Cerebrolysin inhibits lipid peroxidation induced by insulin hypoglycemia in the brain and heart of mice.

Patocková J, Krsiak M, Marhol P, Tůmová E

Physiological research1 Jan 2003Cited by 9 (Europe PMC)

PMID12899658 (opens in a new tab)DOI10.33549/physiolres.930342 (opens in a new tab)PepBankPUB-12899658
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with insulin-induced hypoglycemia, Cerebrolysin did not affect serum glucose.

    In plain wordsIn mice with insulin-induced low blood sugar, Cerebrolysin did not change serum glucose.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeSerum glucose
    Study

    mousen: not reported in source

    insulin-induced hypoglycemia
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    100 mg/kg b.w.As given in this study (mouse).

    Source sentences

    Summary
    Although Cerebrolysin was not able to affect serum parameters after subcomatous insulin injection, the drug significantly influenced lipid peroxidation.
    2 context sentences
    Summary · context
    samples were taken to determine several serum parameters (glucose, total protein, triglycerides and lactic acid) and TBARs in the brain and heart.
    Summary · context
    In our model of insulin-induced hypoglycemia, mice were treated with the neuroprotective, peptide-containing drug Cerebrolysin (100 mg/kg b.w.).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with insulin-induced hypoglycemia, Cerebrolysin did not affect serum total protein.

    In plain wordsIn mice with insulin-induced low blood sugar, Cerebrolysin did not change serum total protein.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeSerum total protein
    Study

    mousen: not reported in source

    insulin-induced hypoglycemia
    Outcome group
    Protein and amino acid metabolism · Whole body
    Studied dose
    100 mg/kg b.w.As given in this study (mouse).

    Source sentences

    Summary
    Although Cerebrolysin was not able to affect serum parameters after subcomatous insulin injection, the drug significantly influenced lipid peroxidation.
    2 context sentences
    Summary · context
    samples were taken to determine several serum parameters (glucose, total protein, triglycerides and lactic acid) and TBARs in the brain and heart.
    Summary · context
    In our model of insulin-induced hypoglycemia, mice were treated with the neuroprotective, peptide-containing drug Cerebrolysin (100 mg/kg b.w.).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with insulin-induced hypoglycemia, Cerebrolysin did not affect serum triglycerides.

    In plain wordsIn mice with insulin-induced low blood sugar, Cerebrolysin did not change serum triglycerides.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeSerum triglycerides
    Study

    mousen: not reported in source

    insulin-induced hypoglycemia
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 mg/kg b.w.As given in this study (mouse).

    Source sentences

    Summary
    Although Cerebrolysin was not able to affect serum parameters after subcomatous insulin injection, the drug significantly influenced lipid peroxidation.
    2 context sentences
    Summary · context
    samples were taken to determine several serum parameters (glucose, total protein, triglycerides and lactic acid) and TBARs in the brain and heart.
    Summary · context
    In our model of insulin-induced hypoglycemia, mice were treated with the neuroprotective, peptide-containing drug Cerebrolysin (100 mg/kg b.w.).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with insulin-induced hypoglycemia, Cerebrolysin did not affect serum lactic acid.

    In plain wordsIn mice with insulin-induced low blood sugar, Cerebrolysin did not change serum lactic acid.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeSerum lactic acid
    Study

    mousen: not reported in source

    insulin-induced hypoglycemia
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    100 mg/kg b.w.As given in this study (mouse).

    Source sentences

    Summary
    Although Cerebrolysin was not able to affect serum parameters after subcomatous insulin injection, the drug significantly influenced lipid peroxidation.
    2 context sentences
    Summary · context
    samples were taken to determine several serum parameters (glucose, total protein, triglycerides and lactic acid) and TBARs in the brain and heart.
    Summary · context
    In our model of insulin-induced hypoglycemia, mice were treated with the neuroprotective, peptide-containing drug Cerebrolysin (100 mg/kg b.w.).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with insulin-induced hypoglycemia, a single Cerebrolysin injection decreased brain TBARs levels.

    In plain wordsIn mice with insulin-induced low blood sugar, Cerebrolysin reduced brain markers of lipid damage.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBrain TBARs
    Study

    mousen: not reported in source

    insulin-induced hypoglycemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 mg/kg b.w.As given in this study (mouse).

    Source sentences

    Summary
    A single injection of Cerebrolysin already decreased TBARs levels in the brain and heart tissue.
    1 context sentence
    Summary · context
    In our model of insulin-induced hypoglycemia, mice were treated with the neuroprotective, peptide-containing drug Cerebrolysin (100 mg/kg b.w.).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with insulin-induced hypoglycemia, a single Cerebrolysin injection decreased heart TBARs levels.

    In plain wordsIn mice with insulin-induced low blood sugar, Cerebrolysin reduced heart markers of lipid damage.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseHeart TBARs
    Study

    mousen: not reported in source

    insulin-induced hypoglycemia
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    100 mg/kg b.w.As given in this study (mouse).

    Source sentences

    Summary
    A single injection of Cerebrolysin already decreased TBARs levels in the brain and heart tissue.
    1 context sentence
    Summary · context
    In our model of insulin-induced hypoglycemia, mice were treated with the neuroprotective, peptide-containing drug Cerebrolysin (100 mg/kg b.w.).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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