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Study · Animal study (in vivo) · rat · 2003

2 results

[Structural and functional organization of the cerebral cortex neurons in rats with various resistance to emotional stress following administration of delta-sleep-inducing peptide].

Bogolepov NN, Popova EN, Koplik EV, Krivitskaia GN, Sudakov KV

Morfologiia (Saint Petersburg, Russia)1 Jan 2003

PMID12891772 (opens in a new tab)PepBankPUB-12891772
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats given DSIP before stress exposure, no ischemically damaged cells were found in sensomotor cortex layer V in any group.

    In plain wordsIn rats given DSIP before stress, no ischemically damaged brain cells were found in any group.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseIschemically damaged cortical neurons after stress exposure
    Study

    ratn: not reported in source

    emotional stress exposure in Wistar rats with different resistance to stress
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After DSIP infusion before SE, ischemically damaged cells were not found in any group
    2 context sentences
    Summary · context
    In Wistar rats with different resistance to emotional stress (ES), subjected to stress exposure (SE), the structural organization of neurons in layer V of sensomotor cortex was studied quantitatively in brain sections stained using Nissl's cresyl violet method.
    Summary · context
    One group of animals was injected with delta sleep-inducing peptide (DSIP) 1 hr before SE.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats given DSIP before stress exposure, shrinkage of extremely hyperchromatic cortical neurons was lower in rats predisposed to emotional stress than in resistant rats.

    In plain wordsIn rats given DSIP before stress, brain cell shrinkage was lower in stress-prone rats than in stress-resistant rats.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseShrinkage of extremely hyperchromatic neurons after stress exposure
    Study

    ratn: not reported in source

    emotional stress exposure in Wistar rats with different resistance to stress
    Comparator
    Rats resistant to emotional stress
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while the degree of shrinkage of extremely hyperchromatic neurons was lower in rats predisposed to ES as compared to rats resistant to ES.
    2 context sentences
    Summary · context
    In Wistar rats with different resistance to emotional stress (ES), subjected to stress exposure (SE), the structural organization of neurons in layer V of sensomotor cortex was studied quantitatively in brain sections stained using Nissl's cresyl violet method.
    Summary · context
    One group of animals was injected with delta sleep-inducing peptide (DSIP) 1 hr before SE.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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