[New regulatory peptides in rat stomach secretion (amylin, PGP, semax)].

Maev IV, Dicheva DT

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology1 Jan 2003

PMID12875006PepBankPUB-12875006

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, intraperitoneal semax decreased basal production of hydrochloric acid in the stomach.
In plain wordsIn rats, semax lowered the normal production of stomach acid.
Peptide
Semax
Outcome
DecreaseBasal hydrochloric acid production
Study
ratn: not reported in source
Continuous stomach perfusion
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
The intraperitoneal introduction of these peptides in the doses that proved to have an apparent anti-ulcer effect caused a decrease of both basal production of hydrochloric acid in the stomach and production caused by the irritation of the vagus nerve.
1 context sentence(design, population, supporting numbers)
Summary · context
We showed antisecretory effects of peptides of PGP, semax and a new pancreatic hormone, amylin, on the model of continuous stomach perfusion with the registration of pH, PCO2 as well as the determination of the amount of pepsinogen in the stomach perfusate.
Report a problemFND-1287500601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, intraperitoneal semax decreased hydrochloric acid production caused by irritation of the vagus nerve.
In plain wordsIn rats, semax lowered stomach acid production triggered by nerve stimulation.
Peptide
Semax
Outcome
DecreaseHydrochloric acid production caused by vagus nerve irritation
Study
ratn: not reported in source
Continuous stomach perfusion
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
The intraperitoneal introduction of these peptides in the doses that proved to have an apparent anti-ulcer effect caused a decrease of both basal production of hydrochloric acid in the stomach and production caused by the irritation of the vagus nerve.
1 context sentence(design, population, supporting numbers)
Summary · context
We showed antisecretory effects of peptides of PGP, semax and a new pancreatic hormone, amylin, on the model of continuous stomach perfusion with the registration of pH, PCO2 as well as the determination of the amount of pepsinogen in the stomach perfusate.
Report a problemFND-1287500602
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, semax decreased basal secretion of pepsinogen in the stomach.
In plain wordsIn rats, semax lowered the normal secretion of the stomach enzyme precursor pepsinogen.
Peptide
Semax
Outcome
DecreaseBasal pepsinogen secretion
Study
ratn: not reported in source
Continuous stomach perfusion
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Semax and amylin also decreased basal and stimulated secretion of pepsinogen.
1 context sentence(design, population, supporting numbers)
Summary · context
We showed antisecretory effects of peptides of PGP, semax and a new pancreatic hormone, amylin, on the model of continuous stomach perfusion with the registration of pH, PCO2 as well as the determination of the amount of pepsinogen in the stomach perfusate.
Report a problemFND-1287500603
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, semax decreased stimulated secretion of pepsinogen in the stomach.
In plain wordsIn rats, semax lowered the stimulated secretion of the stomach enzyme precursor pepsinogen.
Peptide
Semax
Outcome
DecreaseStimulated pepsinogen secretion
Study
ratn: not reported in source
Continuous stomach perfusion
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Semax and amylin also decreased basal and stimulated secretion of pepsinogen.
1 context sentence(design, population, supporting numbers)
Summary · context
We showed antisecretory effects of peptides of PGP, semax and a new pancreatic hormone, amylin, on the model of continuous stomach perfusion with the registration of pH, PCO2 as well as the determination of the amount of pepsinogen in the stomach perfusate.
Report a problemFND-1287500604
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, semax caused a short-time increase in basal bicarbonate secretion of the stomach 35 minutes after its introduction.
In plain wordsIn rats, semax briefly raised stomach bicarbonate secretion 35 minutes after it was given.
Peptide
Semax
Outcome
IncreaseBasal bicarbonate secretion
Study
ratn: not reported in source
Continuous stomach perfusion
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Amylin and PGP did not have any effect on basal bicarbonate secretion of the stomach, and semax caused its short-time increase 35 minutes after the introduction.
1 context sentence(design, population, supporting numbers)
Summary · context
We showed antisecretory effects of peptides of PGP, semax and a new pancreatic hormone, amylin, on the model of continuous stomach perfusion with the registration of pH, PCO2 as well as the determination of the amount of pepsinogen in the stomach perfusate.
Report a problemFND-1287500605

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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