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Study · Not a test of the peptide alone · 2003

4 results

The effectiveness of arginine + GHRH test compared with GHRH + GHRP-6 test in diagnosing growth hormone deficiency in adults.

Popovic V, Pekic S, Doknic M, Micic D, Damjanovic S, Zarkovic M, Aimaretti G, Corneli G, Ghigo E, Deiguez C, Casanueva FF

Clinical endocrinology1 Aug 2003Cited by 12 (Europe PMC)

PMID12864804 (opens in a new tab)DOI10.1046/j.1365-2265.2003.01835.x (opens in a new tab)PepBankPUB-12864804
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01HumanNot a test of GHRP-6 aloneObservational studyOther

    In adults with hypopituitarism, a peak GH below 15.0 microg/l after combined GHRH and GHRP‑6 had a sensitivity of 94.4% for diagnosing GH deficiency.

    In plain wordsIn adults with pituitary disease, a GHRH plus GHRP‑6 test correctly picked out 94.4% of people with growth hormone deficiency.

    Peptide
    GHRP-6
    Outcome
    Not applicableSensitivity of GHRH+GHRP-6 test for GH deficiency
    Study

    n = 50

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Sensitivity
    94.4%
    peak GH <15.0 microg/l

    Source sentences

    Summary
    A peak GH level after GHRH + GHRP-6, under 15.0 microg/l had a sensitivity of 94.4% and specificity of 98.8% for diagnosing GHD and area under the ROC curve was 0.99 (95% confidence interval 0.95-0.99).
    2 context sentences
    Summary · context
    Fifty patients presenting with long-standing hypopituitarism and two control groups consisting of 50 healthy subjects in each group [age-, sex- and body mass index (BMI)-matched] participated in a multicentre study.
    Summary · context
    All underwent two provocative tests on different days within 3 months apart: (i) a combined GHRH + GHRP-6 test and (ii) arginine + GHRH test.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02HumanNot a test of GHRP-6 aloneObservational studyOther

    A peak GH below 15.0 microg/l after combined GHRH and GHRP‑6 had a specificity of 98.8% for diagnosing GH deficiency.

    In plain wordsA GHRH plus GHRP‑6 test correctly ruled out growth hormone deficiency in 98.8% of people without it.

    Peptide
    GHRP-6
    Outcome
    Not applicableSpecificity of GHRH+GHRP-6 test for GH deficiency
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Specificity
    98.8%
    peak GH <15.0 microg/l

    Source sentences

    Summary
    A peak GH level after GHRH + GHRP-6, under 15.0 microg/l had a sensitivity of 94.4% and specificity of 98.8% for diagnosing GHD and area under the ROC curve was 0.99 (95% confidence interval 0.95-0.99).
    2 context sentences
    Summary · context
    Fifty patients presenting with long-standing hypopituitarism and two control groups consisting of 50 healthy subjects in each group [age-, sex- and body mass index (BMI)-matched] participated in a multicentre study.
    Summary · context
    All underwent two provocative tests on different days within 3 months apart: (i) a combined GHRH + GHRP-6 test and (ii) arginine + GHRH test.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03HumanNot a test of GHRP-6 aloneObservational studyOther

    The area under the ROC curve of the combined GHRH and GHRP‑6 test for diagnosing GH deficiency was 0.99.

    In plain wordsThe GHRH plus GHRP‑6 test was very accurate at telling growth hormone deficiency from normal.

    Peptide
    GHRP-6
    Outcome
    Not applicableArea under the ROC curve of GHRH+GHRP-6 test
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    AUC ROC
    0.99
    GHRH + GHRP-6 test

    Source sentences

    Summary
    A peak GH level after GHRH + GHRP-6, under 15.0 microg/l had a sensitivity of 94.4% and specificity of 98.8% for diagnosing GHD and area under the ROC curve was 0.99 (95% confidence interval 0.95-0.99).
    2 context sentences
    Summary · context
    Fifty patients presenting with long-standing hypopituitarism and two control groups consisting of 50 healthy subjects in each group [age-, sex- and body mass index (BMI)-matched] participated in a multicentre study.
    Summary · context
    All underwent two provocative tests on different days within 3 months apart: (i) a combined GHRH + GHRP-6 test and (ii) arginine + GHRH test.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 04HumanNot a test of GHRP-6 aloneObservational studyOther

    The increment in serum GH after GHRH plus GHRP‑6 correlated positively with that after arginine plus GHRH (r = 0.749), showing high concordance.

    In plain wordsThe growth hormone rise after GHRH plus GHRP‑6 closely matched the rise after arginine plus GHRH.

    Peptide
    GHRP-6
    Outcome
    Not applicableConcordance of GH increments between GHRH+GHRP-6 and arginine+GHRH tests
    Study

    n: not reported in source

    Comparator
    Arginine + GHRH test
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Correlation r
    0.749
    GH increment, GHRH+GHRP-6 versus arginine+GHRH

    Source sentences

    Summary
    The relationship between the increment in serum GH following GHRH + GHRP-6 and arginine + GHRH test was positive, i.e. r = 0.749, P = 0.001.Thus, there was high concordance between both tests.
    2 context sentences
    Summary · context
    Fifty patients presenting with long-standing hypopituitarism and two control groups consisting of 50 healthy subjects in each group [age-, sex- and body mass index (BMI)-matched] participated in a multicentre study.
    Summary · context
    All underwent two provocative tests on different days within 3 months apart: (i) a combined GHRH + GHRP-6 test and (ii) arginine + GHRH test.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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