Skip to content

Study · Animal study (in vivo) · mouse · 2003

4 results

Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin.

Rahmouni K, Haynes WG, Morgan DA, Mark AL

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Jul 2003Cited by 151 (Europe PMC)

PMID12853417 (opens in a new tab)PMCIDPMC6740337 (opens in a new tab)DOI10.1523/jneurosci.23-14-05998.2003 (opens in a new tab)PepBankPUB-12853417
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In control mice, intracerebroventricular MTII caused a significant, dose-dependent increase in renal sympathetic nerve activity.

    In plain wordsIn mice, MTII injected into the brain raised nerve activity to the kidney, and a higher dose gave a larger rise.

    Peptide
    Melanotan II
    Outcome
    IncreaseRenal sympathetic nerve activity (RSNA) in control mice
    Study

    mousen: not reported in source

    Outcome group
    Brain and neuronal activity · Cardiovascular
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    ICV administration of leptin and MTII caused a significant and dose-dependent increase in RSNA in control mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In leptin receptor-deficient db/db mice, the renal sympathetic response to MTII was markedly attenuated compared with control mice.

    In plain wordsIn mice without leptin receptors, MTII raised kidney nerve activity much less than in control mice.

    Peptide
    Melanotan II
    Outcome
    DecreaseRSNA response to MTII in leptin receptor-deficient (db/db) mice
    Study

    mousen: not reported in source

    Comparator
    Control mice
    Outcome group
    Brain and neuronal activity · Cardiovascular
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Interestingly, db/db mice exhibited markedly attenuated RSNA responses to ICV administration of MTII.
    1 context sentence
    Summary · context
    We compared the effects of intracerebroventricular (ICV) administration of leptin, insulin, MC-3/4R agonist (MTII), and corticotrophin-releasing factor (CRF) on RSNA in leptin receptor-deficient (db/db) mice, MC-4R knock-out mice, and their wild-type controls
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In heterozygous MC-4R knock-out mice, the renal sympathetic response to MTII was attenuated.

    In plain wordsIn mice missing one copy of the MC-4R gene, MTII raised kidney nerve activity less than in normal mice.

    Peptide
    Melanotan II
    Outcome
    DecreaseRSNA response to MTII in heterozygous MC-4R knock-out mice
    Study

    mousen: not reported in source

    Comparator
    Wild-type controls
    Outcome group
    Brain and neuronal activity · Cardiovascular
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    In the heterozygous and homozygous MC-4R knock-out mice, the RSNA response to MTII was attenuated
    1 context sentence
    Summary · context
    We compared the effects of intracerebroventricular (ICV) administration of leptin, insulin, MC-3/4R agonist (MTII), and corticotrophin-releasing factor (CRF) on RSNA in leptin receptor-deficient (db/db) mice, MC-4R knock-out mice, and their wild-type controls
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In homozygous MC-4R knock-out mice, the renal sympathetic response to MTII was abolished.

    In plain wordsIn mice missing both copies of the MC-4R gene, MTII no longer raised kidney nerve activity.

    Peptide
    Melanotan II
    Outcome
    DecreaseRSNA response to MTII in homozygous MC-4R knock-out mice
    Study

    mousen: not reported in source

    Comparator
    Wild-type controls
    Outcome group
    Brain and neuronal activity · Cardiovascular
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    In the heterozygous and homozygous MC-4R knock-out mice, the RSNA response to MTII was attenuated and abolished, respectively
    1 context sentence
    Summary · context
    We compared the effects of intracerebroventricular (ICV) administration of leptin, insulin, MC-3/4R agonist (MTII), and corticotrophin-releasing factor (CRF) on RSNA in leptin receptor-deficient (db/db) mice, MC-4R knock-out mice, and their wild-type controls

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.