Skip to content

Study · Other design · 2003

4 results

PT-141: a melanocortin agonist for the treatment of sexual dysfunction.

Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY

Annals of the New York Academy of Sciences1 Jun 2003Cited by 75 (Europe PMC)

PMID12851303 (opens in a new tab)DOI10.1111/j.1749-6632.2003.tb03167.x (opens in a new tab)PepBankPUB-12851303
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 1 result from people.

  1. 01HumanOther designEfficacy outcome

    In normal men and in men with erectile dysfunction, PT‑141 produced a rapid, dose-dependent increase in erectile activity.

    In plain wordsIn healthy men and men with erectile dysfunction, PT‑141 quickly raised erectile activity, more so at higher doses.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    IncreaseErectile activity
    Study

    n: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of PT-141 to normal men and to patients with erectile dysfunction resulted in a rapid dose-dependent increase in erectile activity.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, administration of PT‑141 resulted in penile erections.

    In plain wordsIn rats, PT‑141 caused penile erections.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    IncreasePenile erection
    Study

    ratn: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of PT-141 to rats and nonhuman primates results in penile erections.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In nonhuman primates, administration of PT‑141 resulted in penile erections.

    In plain wordsIn nonhuman primates, PT‑141 caused penile erections.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    IncreasePenile erection
    Study

    nonhuman primaten: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of PT-141 to rats and nonhuman primates results in penile erections.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, systemic PT‑141 activated hypothalamic neurons, shown by increased c-Fos immunoreactivity.

    In plain wordsIn rats, PT‑141 given into the body switched on nerve cells in the hypothalamus.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    Increasec-Fos immunoreactivity in hypothalamus
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · systemicAs given in this study (rat).

    Source sentences

    Summary
    Systemic administration of PT-141 to rats activates neurons in the hypothalamus as shown by an increase in c-Fos immunoreactivity.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.