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Study · Animal study (in vivo) · mouse · 2003

1 result

Syndecan-3 modulates food intake by interacting with the melanocortin/AgRP pathway.

Reizes O, Benoit SC, Strader AD, Clegg DJ, Akunuru S, Seeley RJ

Annals of the New York Academy of Sciences1 Jun 2003Cited by 48 (Europe PMC)

PMID12851299 (opens in a new tab)DOI10.1111/j.1749-6632.2003.tb03163.x (opens in a new tab)PepBankPUB-12851299
Publisher pagePubMedAsk about this study
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice lacking syndecan-3, food intake was more sensitive to inhibition by the melanocortin agonist MTII.

    In plain wordsIn mice lacking syndecan-3, food intake was more sensitive to the reducing effect of MTII.

    Peptide
    Melanotan II
    Outcome
    DecreaseInhibition of food intake by MTII in syndecan-3-deficient mice
    Study

    mousen: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Consistent with this hypothesis, mice lacking syndecan-3, which therefore would be predicted to have less effective AgRP, are more sensitive to inhibition of food intake by the melanocortin agonist MTII.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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