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Study · In vitro (cells) · 2003

1 result

Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells.

Wetterau LA, Francis MJ, Ma L, Cohen P

The Journal of clinical endocrinology and metabolism1 Jul 2003Cited by 40 (Europe PMC)

PMID12843187 (opens in a new tab)DOI10.1210/jc.2002-021326 (opens in a new tab)PepBankPUB-12843187
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human prostate cancer cell lines, Long-R3 IGF-I raised telomerase activity about 3-fold.

    In plain wordsIn lab tests on prostate cancer cells, Long-R3 IGF-I raised telomerase activity about 3-fold.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseTelomerase activity
    Study

    humann: not reported in source

    Human prostate cancer cell lines (LAPC-4, PC-3, DU-145)
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Measurements

    Telomerase activity enhancement
    3-fold
    Long-R3 IGF-I

    Source sentences

    Summary
    A similar 3-fold enhancement (P < 0.01) was noted in response to Long-R3 IGF-I, but not in response to [Ala(31),Leu(60)]IGF-I.
    1 context sentence
    Summary · context
    Telomerase activity was assayed in LAPC-4, PC-3, and DU-145 prostate cancer cell lines treated with and without IGF-I/IGF-I analogs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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