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Study · Animal study (in vivo) · rat · 2003

3 results

Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II.

Scarpace PJ, Matheny M, Zolotukhin S, Tümer N, Zhang Y

Neuropharmacology1 Aug 2003Cited by 37 (Europe PMC)

PMID12842127 (opens in a new tab)DOI10.1016/s0028-3908(03)00158-8 (opens in a new tab)PepBankPUB-12842127
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In leptin-resistant young rats, MT II reduced food intake.

    In plain wordsIn rats made resistant to leptin, MT II reduced food intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake after MT II in leptin-resistant rats
    Study

    ratn: not reported in source

    leptin-induced leptin-resistant rats (rAAV-leptin)
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The same rats were administered MT II subsequently, and both the leptin-resistant and leptin-responsive groups displayed reduced food intake.
    1 context sentence
    Summary · context
    Recombinant adeno-associated virus encoding rat leptin cDNA (rAAV-leptin) or control viral vector were administered into young, lean rats for 300 days, and food consumption, body weight, oxygen consumption, serum leptin, and leptin signal transduction were measured.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In leptin-responsive control young rats, MT II reduced food intake.

    In plain wordsIn control rats that still responded to leptin, MT II reduced food intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake after MT II in leptin-responsive rats
    Study

    ratn: not reported in source

    control rats given a control viral vector (leptin-responsive)
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The same rats were administered MT II subsequently, and both the leptin-resistant and leptin-responsive groups displayed reduced food intake.
    1 context sentence
    Summary · context
    Recombinant adeno-associated virus encoding rat leptin cDNA (rAAV-leptin) or control viral vector were administered into young, lean rats for 300 days, and food consumption, body weight, oxygen consumption, serum leptin, and leptin signal transduction were measured.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In leptin-resistant young rats, the anorexic response to MT II persisted longer than in leptin-responsive rats.

    In plain wordsIn rats, the food-intake drop after MT II lasted longer in leptin-resistant rats than in leptin-responsive rats.

    Peptide
    Melanotan II
    Outcome
    IncreaseDuration of anorexic response to MT II
    Study

    ratn: not reported in source

    leptin-induced leptin-resistant rats (rAAV-leptin)
    Comparator
    Leptin-responsive control rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, the anorexic response persisted longer in the leptin-resistant group.
    1 context sentence
    Summary · context
    Recombinant adeno-associated virus encoding rat leptin cDNA (rAAV-leptin) or control viral vector were administered into young, lean rats for 300 days, and food consumption, body weight, oxygen consumption, serum leptin, and leptin signal transduction were measured.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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