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Study · Measured the body's own peptide · 2003

3 results

Vasoactive intestinal peptide (VIP) and VIP mRNA decrease in the cerebral cortex of nNOS knock-out(-/-) mice.

Kim MJ, Joo KM, Chung YH, Lee YJ, Kim J, Lee BH, Shin DH, Lee KH, Cha CI

Brain research1 Jul 2003Cited by 7 (Europe PMC)

PMID12834919 (opens in a new tab)DOI10.1016/s0006-8993(03)02950-0 (opens in a new tab)PepBankPUB-12834919
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In the cerebral cortex of nNOS knock-out mice, the number of VIP-immunoreactive neurons was significantly lower than in control mice.

    In plain wordsIn mice lacking nNOS, the brain cortex had fewer neurons that carry the body's own VIP than in normal mice.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP-immunoreactive neurons
    Study

    mousen: not reported in source

    nNOS knock-out mice, cerebral cortex
    Comparator
    Control mice
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    The nNOS((-/-)) mice had significantly fewer VIP-immunoreactive neurons than the control mice
    1 context sentence
    Summary · context
    We therefore examined changes in VIP expression in the cerebral cortex of nNOS knock-out(-/-) mice using immunohistochemistry and in situ hybridization.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In the cerebral cortex of nNOS knock-out mice, VIP mRNA was decreased compared with control mice.

    In plain wordsIn mice lacking nNOS, the brain cortex had less of the body's own VIP message than in normal mice.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP mRNA
    Study

    mousen: not reported in source

    nNOS knock-out mice, cerebral cortex
    Comparator
    Control mice
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    the VIP mRNA as well as the VIP-immunoreactivity of the individual neuron was decreased in the nNOS((-/-)) mice.
    1 context sentence
    Summary · context
    We therefore examined changes in VIP expression in the cerebral cortex of nNOS knock-out(-/-) mice using immunohistochemistry and in situ hybridization.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In the cerebral cortex of nNOS knock-out mice, VIP immunoreactivity of the individual neuron was decreased.

    In plain wordsIn mice lacking nNOS, each cortex neuron held less of the body's own VIP than in normal mice.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP immunoreactivity per neuron
    Study

    mousen: not reported in source

    nNOS knock-out mice, cerebral cortex
    Comparator
    Control mice
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    the VIP mRNA as well as the VIP-immunoreactivity of the individual neuron was decreased in the nNOS((-/-)) mice.
    1 context sentence
    Summary · context
    We therefore examined changes in VIP expression in the cerebral cortex of nNOS knock-out(-/-) mice using immunohistochemistry and in situ hybridization.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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