In ovariectomized female rats not given estrogen, tamoxifen and ethynylestradiol increased oxytocin receptor binding in the ventromedial nucleus of the hypothalamus.
In plain wordsIn female rats, tamoxifen and a synthetic estrogen increased oxytocin receptor binding in a brain region; oxytocin itself was not given.
- Peptide
- Oxytocin
- Outcome
- IncreaseOxytocin receptor binding in the ventromedial hypothalamus
- Study
ratn: not reported in source
ovariectomized female rats- Comparator
- Sesame oil
- Outcome group
- Receptor activity and mechanism · Endocrine and hormones
Source sentences
TAMOX and EE increased oxytocin receptor binding in the ventromedial nucleus of the hypothalamus (VMN) in the absence of estrogen in both groups 1 and 2.
1 context sentence(design, population, supporting numbers)
Two groups of adult, ovariectomized, female rats (n=30 per group) were injected with TAMOX (5 mg/kg), EE (0.1 mg/kg), or sesame oil daily for 14 days.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.