MTII administered peripherally reduces fat without invoking apoptosis in rats.

Choi YH, Li C, Hartzell DL, Lin J, Della-Fera MA, Baile CA

Physiology & behavior1 Jul 2003Cited by 12 (Europe PMC)

PMID12834806DOI10.1016/s0031-9384(03)00118-5PepBankPUB-12834806

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, MTII reduced food intake compared with pair-fed and saline-treated controls.
In plain wordsIn rats, melanotan II reduced food intake compared with pair-fed and saline-treated rats.
Peptide
Melanotan II
Outcome
DecreaseFood intake
Study
ratn = 8
Rats given MTII, saline or pair-feeding
Comparator
Pair-fed and saline-treated controls
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
2 mg/kg once daily · intraperitoneal · 4 daysAs given in this study (rat).
Source sentences
Summary
MTII reduced food and water intake and body weight gain (P<.05) and decreased body temperature compared to PF and saline-treated control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether MTII also mediates adipose apoptosis induced by leptin treatment, two groups of rats (n=8) received MTII (2 mg/kg, i.p.) or saline (2 ml/kg) once daily for 4 days and had free access to food and water, and a third group was injected with saline and pair-fed (PF) to MTII treated rats.
Report a problemFND-1283480601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, MTII reduced water intake compared with pair-fed and saline-treated controls.
In plain wordsIn rats, melanotan II reduced water intake compared with pair-fed and saline-treated rats.
Peptide
Melanotan II
Outcome
DecreaseWater intake
Study
ratn = 8
Rats given MTII, saline or pair-feeding
Comparator
Pair-fed and saline-treated controls
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
2 mg/kg once daily · intraperitoneal · 4 daysAs given in this study (rat).
Source sentences
Summary
MTII reduced food and water intake and body weight gain (P<.05) and decreased body temperature compared to PF and saline-treated control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether MTII also mediates adipose apoptosis induced by leptin treatment, two groups of rats (n=8) received MTII (2 mg/kg, i.p.) or saline (2 ml/kg) once daily for 4 days and had free access to food and water, and a third group was injected with saline and pair-fed (PF) to MTII treated rats.
Report a problemFND-1283480602
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, MTII reduced body weight gain compared with pair-fed and saline-treated controls.
In plain wordsIn rats, melanotan II reduced weight gain compared with pair-fed and saline-treated rats.
Peptide
Melanotan II
Outcome
DecreaseBody weight gain
Study
ratn = 8
Rats given MTII, saline or pair-feeding
Comparator
Pair-fed and saline-treated controls
Outcome group
Body weight · Metabolic and weight
Studied dose
2 mg/kg once daily · intraperitoneal · 4 daysAs given in this study (rat).
Source sentences
Summary
MTII reduced food and water intake and body weight gain (P<.05) and decreased body temperature compared to PF and saline-treated control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether MTII also mediates adipose apoptosis induced by leptin treatment, two groups of rats (n=8) received MTII (2 mg/kg, i.p.) or saline (2 ml/kg) once daily for 4 days and had free access to food and water, and a third group was injected with saline and pair-fed (PF) to MTII treated rats.
Report a problemFND-1283480603
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, MTII decreased body temperature compared with pair-fed and saline-treated controls.
In plain wordsIn rats, melanotan II lowered body temperature compared with pair-fed and saline-treated rats.
Peptide
Melanotan II
Outcome
DecreaseBody temperature
Study
ratn = 8
Rats given MTII, saline or pair-feeding
Comparator
Pair-fed and saline-treated controls
Outcome group
Body temperature · Metabolic and weight
Studied dose
2 mg/kg once daily · intraperitoneal · 4 daysAs given in this study (rat).
Source sentences
Summary
MTII reduced food and water intake and body weight gain (P<.05) and decreased body temperature compared to PF and saline-treated control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether MTII also mediates adipose apoptosis induced by leptin treatment, two groups of rats (n=8) received MTII (2 mg/kg, i.p.) or saline (2 ml/kg) once daily for 4 days and had free access to food and water, and a third group was injected with saline and pair-fed (PF) to MTII treated rats.
Report a problemFND-1283480604
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, MTII reduced retroperitoneal white adipose tissue mass by 46.3%, but pair-feeding did not, compared with saline controls.
In plain wordsIn rats, melanotan II reduced abdominal white fat mass compared with saline, and pair-feeding did not.
Peptide
Melanotan II
Outcome
DecreaseRetroperitoneal white adipose tissue mass
Study
ratn = 8
Rats given MTII, saline or pair-feeding
Comparator
Saline control
Outcome group
Body weight · Metabolic and weight
Studied dose
2 mg/kg once daily · intraperitoneal · 4 daysAs given in this study (rat).
Measurements
Retroperitoneal WAT mass reduction
46.3%
MTII versus saline
Source sentences
Summary
Retroperitoneal white adipose tissue (WAT) mass and epididymal WAT mass were reduced 46.3% and 21.1%, respectively (P<.05), after MTII, but not after PF, compared with the saline control rats.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether MTII also mediates adipose apoptosis induced by leptin treatment, two groups of rats (n=8) received MTII (2 mg/kg, i.p.) or saline (2 ml/kg) once daily for 4 days and had free access to food and water, and a third group was injected with saline and pair-fed (PF) to MTII treated rats.
Report a problemFND-1283480605
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, MTII reduced epididymal white adipose tissue mass by 21.1%, but pair-feeding did not, compared with saline controls.
In plain wordsIn rats, melanotan II reduced epididymal white fat mass compared with saline, and pair-feeding did not.
Peptide
Melanotan II
Outcome
DecreaseEpididymal white adipose tissue mass
Study
ratn = 8
Rats given MTII, saline or pair-feeding
Comparator
Saline control
Outcome group
Body weight · Metabolic and weight
Studied dose
2 mg/kg once daily · intraperitoneal · 4 daysAs given in this study (rat).
Measurements
Epididymal WAT mass reduction
21.1%
MTII versus saline
Source sentences
Summary
Retroperitoneal white adipose tissue (WAT) mass and epididymal WAT mass were reduced 46.3% and 21.1%, respectively (P<.05), after MTII, but not after PF, compared with the saline control rats.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether MTII also mediates adipose apoptosis induced by leptin treatment, two groups of rats (n=8) received MTII (2 mg/kg, i.p.) or saline (2 ml/kg) once daily for 4 days and had free access to food and water, and a third group was injected with saline and pair-fed (PF) to MTII treated rats.
Report a problemFND-1283480606
07AnimalAnimal study (in vivo)Efficacy outcome
In rats, MTII decreased brown fat weight by 25.0%; pair-fed rats also had decreased brown fat weight.
In plain wordsIn rats, melanotan II reduced brown fat weight, and pair-fed rats also lost brown fat.
Peptide
Melanotan II
Outcome
DecreaseBrown fat weight
Study
ratn = 8
Rats given MTII, saline or pair-feeding
Outcome group
Body weight · Metabolic and weight
Studied dose
2 mg/kg once daily · intraperitoneal · 4 daysAs given in this study (rat).
Measurements
Brown fat weight decrease
25%
MTII
Source sentences
Summary
Both MTII- (25.0%) and PF (33.3%)-treated rats had decreased brown fat weight (P<.05)
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether MTII also mediates adipose apoptosis induced by leptin treatment, two groups of rats (n=8) received MTII (2 mg/kg, i.p.) or saline (2 ml/kg) once daily for 4 days and had free access to food and water, and a third group was injected with saline and pair-fed (PF) to MTII treated rats.
Report a problemFND-1283480607
08AnimalAnimal study (in vivo)Efficacy outcome
In rats, muscle mass remained unchanged after MTII.
In plain wordsIn rats, melanotan II did not change muscle mass.
Peptide
Melanotan II
Outcome
No significant changeMuscle mass
Study
ratn = 8
Rats given MTII, saline or pair-feeding
Outcome group
Body weight · Metabolic and weight
Studied dose
2 mg/kg once daily · intraperitoneal · 4 daysAs given in this study (rat).
Source sentences
Summary
whereas muscle mass remained unchanged.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether MTII also mediates adipose apoptosis induced by leptin treatment, two groups of rats (n=8) received MTII (2 mg/kg, i.p.) or saline (2 ml/kg) once daily for 4 days and had free access to food and water, and a third group was injected with saline and pair-fed (PF) to MTII treated rats.
Report a problemFND-1283480608
09AnimalAnimal study (in vivo)Mechanism
In rats, serum free fatty acid concentrations did not differ between MTII and control groups, but increased by 56.4% in the pair-fed group.
In plain wordsIn rats, melanotan II did not change blood free fatty acids compared with controls, while pair-feeding raised them.
Peptide
Melanotan II
Outcome
No significant changeSerum free fatty acid concentration
Study
ratn = 8
Rats given MTII, saline or pair-feeding
Comparator
Saline control
Outcome group
Lipids · Metabolic and weight
Studied dose
2 mg/kg once daily · intraperitoneal · 4 daysAs given in this study (rat).
Source sentences
Summary
Free fatty acid concentrations in serum were not different between MTII and control groups, but increased by 56.4% in PF group.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether MTII also mediates adipose apoptosis induced by leptin treatment, two groups of rats (n=8) received MTII (2 mg/kg, i.p.) or saline (2 ml/kg) once daily for 4 days and had free access to food and water, and a third group was injected with saline and pair-fed (PF) to MTII treated rats.
Report a problemFND-1283480609
10AnimalAnimal study (in vivo)Mechanism
In rats, a DNA fragmentation assay did not support a role for MTII as an apoptotic signal in any fat tissue tested.
In plain wordsIn rats, a test for fat cell death did not show that melanotan II triggers it in any fat tissue tested.
Peptide
Melanotan II
Outcome
No significant changeAdipose apoptosis (DNA fragmentation)
Study
ratn = 8
Rats given MTII, saline or pair-feeding
Outcome group
Body weight · Metabolic and weight
Studied dose
2 mg/kg once daily · intraperitoneal · 4 daysAs given in this study (rat).
Source sentences
Summary
DNA fragmentation assay did not support a role for MTII as an apoptotic signal in any of the fat tissues tested.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether MTII also mediates adipose apoptosis induced by leptin treatment, two groups of rats (n=8) received MTII (2 mg/kg, i.p.) or saline (2 ml/kg) once daily for 4 days and had free access to food and water, and a third group was injected with saline and pair-fed (PF) to MTII treated rats.
Report a problemFND-1283480610

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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