Galanin affects vasopressin and oxytocin release from the hypothalamo-neurohypophysial system in haemorrahaged rats.

Ciosek J, Cisowska A, Dabrowski R

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Jun 2003Cited by 5 (Europe PMC)

PMID12832724PepBankPUB-12832724

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Mechanism
In non-haemorrhaged rats, central galanin did not change oxytocin content in the hypothalamus and neurohypophysis or its plasma concentration.
In plain wordsIn rats without blood loss, galanin given in the brain did not change the body's own oxytocin in tissue or blood.
Peptide
Oxytocin
Outcome
No significant changeOxytocin content and plasma level after galanin in non-haemorrhaged rats
Study
rat (Wistar)n: not reported in source
haemorrhaged male rats
Comparator
Vehicle
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Gal i.c.v. treatment did not alter vasopressin and oxytocin content both in the hypothalamus and neurohypophysis as well as their concentration in blood plasma of not haemorrhaged rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of centrally administered galanin (Gal; 100 pM i.c.v.) on the hypothalamo-neurohypophysial storage as well as blood plasma level of vasopressin and oxytocin was estimated in haemorrhaged (1 ml per 100 g b.w.) male Wistar rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1283272401
02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats injected with vehicle, haemorrhage decreased hypothalamic and neurohypophysial oxytocin storage.
In plain wordsIn rats, blood loss lowered the body's own oxytocin stored in the brain and pituitary.
Peptide
Oxytocin
Outcome
DecreaseHypothalamic and neurohypophysial oxytocin storage after haemorrhage
Study
rat (Wistar)n: not reported in source
haemorrhaged male rats
Comparator
Vehicle-injected, not haemorrhaged
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Haemorrhage decreased the hypothalamic and neurohypophysial vasopressin and oxytocin storage
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of centrally administered galanin (Gal; 100 pM i.c.v.) on the hypothalamo-neurohypophysial storage as well as blood plasma level of vasopressin and oxytocin was estimated in haemorrhaged (1 ml per 100 g b.w.) male Wistar rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1283272402
03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats injected with vehicle, haemorrhage increased plasma oxytocin level.
In plain wordsIn rats, blood loss raised the body's own oxytocin level in blood.
Peptide
Oxytocin
Outcome
IncreasePlasma oxytocin after haemorrhage
Study
rat (Wistar)n: not reported in source
haemorrhaged male rats
Comparator
Vehicle-injected, not haemorrhaged
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
but increased the neurohormones plasma level in animals injected with vehicle solution.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of centrally administered galanin (Gal; 100 pM i.c.v.) on the hypothalamo-neurohypophysial storage as well as blood plasma level of vasopressin and oxytocin was estimated in haemorrhaged (1 ml per 100 g b.w.) male Wistar rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1283272403
04AnimalEndogenous levelAnimal study (in vivo)Mechanism
In haemorrhaged rats, central galanin inhibited the haemorrhage-induced increase in plasma oxytocin.
In plain wordsIn rats, galanin given in the brain blunted the rise in the body's own oxytocin in blood after blood loss.
Peptide
Oxytocin
Outcome
DecreaseHaemorrhage-induced rise in plasma oxytocin with galanin
Study
rat (Wistar)n: not reported in source
haemorrhaged male rats
Comparator
Vehicle
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
During the haemorrhage, the increase in plasma vasopressin and oxytocin was inhibited in rats previously treated i.c.v. with galanin.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of centrally administered galanin (Gal; 100 pM i.c.v.) on the hypothalamo-neurohypophysial storage as well as blood plasma level of vasopressin and oxytocin was estimated in haemorrhaged (1 ml per 100 g b.w.) male Wistar rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1283272404
05AnimalEndogenous levelAnimal study (in vivo)Mechanism
In haemorrhaged rats, central galanin significantly increased hypothalamic and neurohypophysial oxytocin content.
In plain wordsIn rats with blood loss, galanin given in the brain raised the body's own oxytocin stored in the brain and pituitary.
Peptide
Oxytocin
Outcome
IncreaseHypothalamic and neurohypophysial oxytocin content with galanin after haemorrhage
Study
rat (Wistar)n: not reported in source
haemorrhaged male rats
Comparator
Vehicle
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
The hypothalamic and neurohypophysial vasopressin as well as oxytocin content significantly increased in animals treated with galanin and subsequently haemorrhaged.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of centrally administered galanin (Gal; 100 pM i.c.v.) on the hypothalamo-neurohypophysial storage as well as blood plasma level of vasopressin and oxytocin was estimated in haemorrhaged (1 ml per 100 g b.w.) male Wistar rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1283272405

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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