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Study · In vitro (cells) · chick · 2002

5 results

In vitro models of brain ischemia: the peptidergic drug cerebrolysin protects cultured chick cortical neurons from cell death.

Gutmann B, Hutter-Paier B, Skofitsch G, Windisch M, Gmeinbauer R

Neurotoxicity research1 Feb 2002Cited by 26 (Europe PMC)

PMID12826494 (opens in a new tab)DOI10.1080/10298420290007637 (opens in a new tab)PepBankPUB-12826494
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured chick cortical neurons, Cerebrolysin produced dose-dependent neuroprotection across lesion types.

    In plain wordsIn cells from chicks, Cerebrolysin increased protection as its dose increased across lesion types.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseDose-dependent neuroprotection
    Study

    chickn: not reported in source

    Cultured cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of Cere resulted in dose dependent neuroprotection independent from the kind of lesion.
    1 context sentence
    Summary · context
    In this study these three lesion models were used to investigate the effects of the nootropic drug Cerebrolysin (Cere) on the survival of cortical neurons in culture and on the occurrence of apoptosis.
  2. 02LabIn vitro (cells)Efficacy outcome

    In cultured chick neurons exposed to glutamate, Cerebrolysin almost doubled viability versus lesioned controls.

    In plain wordsIn cells from chicks, Cerebrolysin almost doubled survival after glutamate exposure compared with injured controls.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal viability after glutamate
    Study

    chickn: not reported in source

    Cultured cortical neurons
    Comparator
    Lesioned controls
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the glutamate model the drug almost doubled neuronal viability compared to lesioned controls.
    1 context sentence
    Summary · context
    In this study these three lesion models were used to investigate the effects of the nootropic drug Cerebrolysin (Cere) on the survival of cortical neurons in culture and on the occurrence of apoptosis.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured chick neurons, Cerebrolysin significantly reduced apoptotic cells after acute glutamate exposure.

    In plain wordsIn cells from chicks, Cerebrolysin reduced programmed cell death after acute glutamate exposure.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseApoptosis after glutamate
    Study

    chickn: not reported in source

    Cultured cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After acute glutamate exposure Cere reduced the number of apoptotic cells significantly.
    1 context sentence
    Summary · context
    In this study these three lesion models were used to investigate the effects of the nootropic drug Cerebrolysin (Cere) on the survival of cortical neurons in culture and on the occurrence of apoptosis.
  4. 04LabIn vitro (cells)Efficacy outcome

    In cultured chick neurons, Cerebrolysin showed protective efficacy after iodoacetate-induced cytotoxic hypoxia.

    In plain wordsIn cells from chicks, Cerebrolysin protected neurons after iodoacetate injury.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseProtection after iodoacetate
    Study

    chickn: not reported in source

    Cultured cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In spite of the protective efficacy after cytotoxic hypoxia induced by iodoacetate, the drug significantly increased the number of apoptotic neurons, indicating a shift from necrosis to apoptosis.
    1 context sentence
    Summary · context
    In this study these three lesion models were used to investigate the effects of the nootropic drug Cerebrolysin (Cere) on the survival of cortical neurons in culture and on the occurrence of apoptosis.
  5. 05LabIn vitro (cells)Efficacy outcome

    In cultured chick neurons, Cerebrolysin significantly increased apoptotic neurons after iodoacetate-induced cytotoxic hypoxia.

    In plain wordsIn cells from chicks, Cerebrolysin increased programmed cell death after iodoacetate injury.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseApoptosis after iodoacetate
    Study

    chickn: not reported in source

    Cultured cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In spite of the protective efficacy after cytotoxic hypoxia induced by iodoacetate, the drug significantly increased the number of apoptotic neurons, indicating a shift from necrosis to apoptosis.
    1 context sentence
    Summary · context
    In this study these three lesion models were used to investigate the effects of the nootropic drug Cerebrolysin (Cere) on the survival of cortical neurons in culture and on the occurrence of apoptosis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

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