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Study · Ex vivo tissue · rat · 2003

3 results

Glutamatergic input governs periodicity and synchronization of bursting activity in oxytocin neurons in hypothalamic organotypic cultures.

Israel JM, Le Masson G, Theodosis DT, Poulain DA

The European journal of neuroscience1 Jun 2003Cited by 60 (Europe PMC)

PMID12823469 (opens in a new tab)DOI10.1046/j.1460-9568.2003.02705.x (opens in a new tab)PepBankPUB-12823469
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In organotypic rat hypothalamic slice cultures, applied oxytocin triggered bursts in oxytocin neurons that were not bursting.

    In plain wordsIn lab slices of rat brain tissue, oxytocin triggered bursts of electrical activity in oxytocin neurons that had been quiet.

    Peptide
    Oxytocin
    Outcome
    IncreaseBursting in non-bursting oxytocin neurons
    Study

    ratn: not reported in source

    organotypic hypothalamic slice cultures
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Application of OT triggered bursts in nonbursting neurons
    1 context sentence
    Summary · context
    To investigate the basis of such synchronization, we performed simultaneous intracellular recordings from pairs of OT neurons identified retrospectively by intracellular fluorescent labelling and immunocytochemistry in organotypic slice cultures derived from postnatal rat hypothalamus.
  2. 02LabEx vivo tissueActivity measurement

    In organotypic rat hypothalamic slice cultures, applied oxytocin accelerated bursting activity in oxytocin neurons that were already bursting.

    In plain wordsIn lab slices of rat brain tissue, oxytocin sped up bursting in oxytocin neurons that were already bursting.

    Peptide
    Oxytocin
    Outcome
    IncreaseBursting rate in spontaneously bursting oxytocin neurons
    Study

    ratn: not reported in source

    organotypic hypothalamic slice cultures
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    accelerated bursting activity in spontaneously bursting cells.
    1 context sentence
    Summary · context
    To investigate the basis of such synchronization, we performed simultaneous intracellular recordings from pairs of OT neurons identified retrospectively by intracellular fluorescent labelling and immunocytochemistry in organotypic slice cultures derived from postnatal rat hypothalamus.
  3. 03LabEx vivo tissueActivity measurement

    In organotypic rat hypothalamic slice cultures, vasopressinergic neurons showed no bursting activity and no reaction to oxytocin.

    In plain wordsIn lab slices of rat brain tissue, vasopressin neurons did not react to oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeResponse of vasopressinergic neurons to oxytocin
    Study

    ratn: not reported in source

    organotypic hypothalamic slice cultures
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These cultures included rare vasopressinergic neurons showing no bursting activity and no reaction to OT.
    1 context sentence
    Summary · context
    To investigate the basis of such synchronization, we performed simultaneous intracellular recordings from pairs of OT neurons identified retrospectively by intracellular fluorescent labelling and immunocytochemistry in organotypic slice cultures derived from postnatal rat hypothalamus.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

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