In rats on a high-fat diet, MTII given into the third ventricle reduced food intake less than in rats on a low-fat diet.
In plain wordsIn rats, MTII lowered food intake less in rats fed a high-fat diet than in rats fed a low-fat diet.
- Peptide
- Melanotan II
- Outcome
- DecreaseFood intake reduction by MTII, high-fat versus low-fat diet
- Study
ratn: not reported in source
- Comparator
- Low-fat diet rats
- Outcome group
- Appetite and food intake · Metabolic and weight
- Studied dose
- 0.1, 0.3, and 1.0 nmol · third cerebral ventricleAs given in this study (rat).
Source sentences
MTII given into the third cerebral ventricle in doses of 0.1, 0.3, and 1.0 nmol was less effective at reducing food intake in HF rats than in LF rats.
1 context sentence(design, population, supporting numbers)
To evaluate this hypothesis, we compared the efficacy of the MC3/4 receptor agonist, MTII, to reduce food intake in rats fed carefully matched HF or low-fat (LF) diets for 12 wk.