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Study · Ex vivo tissue · rat (wistar) · 2003

2 results

Effect of a synthetic pineal tetrapeptide (Ala-Glu-Asp-GLy) on melatonin secretion by the pineal gland of young and old rats.

Djeridane Y, Khavinson VKh, Anisimov VN, Touitou Y

Journal of endocrinological investigation1 Mar 2003Cited by 7 (Europe PMC)

PMID12809170 (opens in a new tab)DOI10.1007/bf03345159 (opens in a new tab)PepBankPUB-12809170
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In perifused pineal glands from young and old rats, the tetrapeptide had no significant effect on melatonin secretion.

    In plain wordsIn lab tests on rat pineal glands, the peptide did not change melatonin release in young or old rats.

    Peptide
    Epitalon
    Outcome
    No significant changePineal melatonin secretion
    Study

    Rat (Wistar)n: not reported in source

    Perifused pineal gland
    Outcome group
    Aging markers · Endocrine and hormones
    Studied dose
    10(-4) to 10(-6) MAs given in this study (Rat (Wistar)).

    Source sentences

    Summary
    Pineal tetrapeptide at the concentrations used (10(-4) to 10(-6) M) had no significant effect upon melatonin secretion whatever the age of the animals, young or old.
    1 context sentence
    Summary · context
    The tetrapeptide effects on pineal gland melatonin secretion were studied in young (9 weeks) and old (27 months) male Wistar rats using a perifusion device.
  2. 02LabEx vivo tissueEfficacy outcome

    In perifused rat pineal glands, the tetrapeptide did not modify the melatonin increase induced by isoproterenol.

    In plain wordsIn lab tests on rat pineal glands, the peptide did not change the melatonin rise caused by isoproterenol.

    Peptide
    Epitalon
    Outcome
    No significant changeIsoproterenol-stimulated pineal melatonin secretion
    Study

    Rat (Wistar)n: not reported in source

    Perifused pineal gland
    Outcome group
    Aging markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also looked at the effect of the tetrapeptide on pineal melatonin stimulated by a beta-adrenergic agonist, isoproterenol. We found that isoproterenol-induced melatonin increase was not modified by the tetrapeptide.
    1 context sentence
    Summary · context
    The tetrapeptide effects on pineal gland melatonin secretion were studied in young (9 weeks) and old (27 months) male Wistar rats using a perifusion device.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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