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Study · Ex vivo tissue · mouse · 2003

2 results

Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity.

Wilkemeyer MF, Chen SY, Menkari CE, Brenneman DE, Sulik KK, Charness ME

Proceedings of the National Academy of Sciences of the United States of America13 Jun 2003Cited by 70 (Europe PMC)

PMID12808140 (opens in a new tab)PMCIDPMC166265 (opens in a new tab)DOI10.1073/pnas.1331636100 (opens in a new tab)PepBankPUB-12808140
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In mouse whole-embryo culture, NAP significantly prevented the ethanol-induced reduction in paired somite number.

    In plain wordsIn lab tests, NAP prevented the reduction in mouse embryo somite number compared with ethanol alone.

    Peptide
    Davunetide
    Outcome
    IncreasePaired somite number after ethanol
    Study

    mousen: not reported in source

    Whole-embryo culture
    Comparator
    Ethanol alone
    Outcome group
    Linear growth · Whole body
    Studied dose
    100 pMAs given in this study (mouse).

    Source sentences

    Summary
    Ethanol significantly reduced the number of paired somites in mouse whole-embryo culture; this effect was prevented significantly by 100 pM NAP or by 100 pM P7A-NAP, but not by 100 pM I6A-NAP.
  2. 02LabEx vivo tissueMechanism

    In mouse whole-embryo culture, the structure-activity relation for NAP prevention of ethanol embryotoxicity resembled ethanol antagonism rather than neuroprotection.

    In plain wordsIn lab tests, NAP structure-activity patterns for preventing mouse embryo toxicity resembled ethanol antagonism patterns rather than neuroprotection patterns.

    Peptide
    Davunetide
    Outcome
    Not applicableStructure-activity relationship of embryotoxicity prevention
    Study

    mousen: not reported in source

    Whole-embryo culture
    Comparator
    Ethanol antagonism and neuroprotection structure-activity relationships
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The structure-activity relation for NAP prevention of ethanol embryotoxicity was similar to that for NAP ethanol antagonism and different from that for NAP neuroprotection.
    1 context sentence
    Summary · context
    Ethanol significantly reduced the number of paired somites in mouse whole-embryo culture; this effect was prevented significantly by 100 pM NAP or by 100 pM P7A-NAP, but not by 100 pM I6A-NAP.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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