In bovine cartilage disks, Des(1‑3)IGF-I did not release bound labeled IGF-I, unlike excess unlabeled IGF-I.
In plain wordsIn lab tests, Des(1‑3)IGF-I did not release bound IGF-I from bovine cartilage, unlike unlabeled IGF-I.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- No significant changeRelease of bound IGF-I
- Study
bovinen: not reported in source
articular cartilage disks- Comparator
- unlabeled IGF-I
- Outcome group
- Receptor activity and mechanism · Musculoskeletal
- Studied dose
- Dose not stated
Source sentences
In contrast, addition of the low-affinity Des(1-3)IGF-I analog did not result in release of bound 125I-IGF-I.
2 context sentences(design, population, supporting numbers)
Addition of excess amounts of unlabeled IGF-I during steady state transport of 125I-IGF-I resulted in release of bound 125I-IGF-I from the tissue, as predicted by the diffusion-reaction model.
Bovine articular cartilage disks were equilibrated in buffer containing 125I-IGF-I and graded levels of unlabeled IGF-I.