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Study · Animal study (in vivo) · rat · 2003

2 results

Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.

Haninec P, Houst'ava L, Stejskal L, Dubový P

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft1 Jun 2003Cited by 19 (Europe PMC)

PMID12801087 (opens in a new tab)DOI10.1016/s0940-9602(03)80030-4 (opens in a new tab)PepBankPUB-12801087
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ventral root avulsion, Cerebrolysin increased motoneuron survival versus untreated controls.

    In plain wordsIn rats with nerve root injury, Cerebrolysin increased motoneuron survival compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMotoneuron survival versus untreated controls
    Study

    ratn: not reported in source

    C5 ventral root avulsion
    Comparator
    Untreated control rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of IGF-I or Cerebrolysin.
    1 context sentence
    Summary · context
    In the present experiments we have tested effects of insulin-like growth factor-I (IGF-I) and Cerebrolysin on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ventral root avulsion, motoneuron survival did not differ significantly between Cerebrolysin and IGF-I.

    In plain wordsIn rats with nerve root injury, motoneuron survival did not differ significantly between Cerebrolysin and IGF-I.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeMotoneuron survival versus IGF-I
    Study

    ratn: not reported in source

    C5 ventral root avulsion
    Comparator
    IGF-I
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    No significant differences were observed between effects of IGF-I and Cerebrolysin in our experimental model.
    2 context sentences
    Summary · context
    In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of IGF-I or Cerebrolysin.
    Summary · context
    In the present experiments we have tested effects of insulin-like growth factor-I (IGF-I) and Cerebrolysin on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

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