Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice.

Popovich IG, Voitenkov BO, Anisimov VN, Ivanov VT, Mikhaleva II, Zabezhinski MA, Alimova IN, Baturin DA, Zavarzina NY, Rosenfeld SV, Semenchenko AV, Yashin AI

Mechanisms of ageing and development1 Jun 2003Cited by 13 (Europe PMC)

PMID12782416DOI10.1016/s0047-6374(03)00082-4PepBankPUB-12782416

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

01AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In female SHR mice, Deltaran did not influence mean life span.
In plain wordsIn mice, Deltaran did not change average life span.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeMean life span
Study
mousen = 108
Female Swiss-derived SHR mice, treated for life
Comparator
Saline control
Outcome group
Mortality · Aging and longevity
Source sentences
Summary
it did not influence mean life span; and it increased by 17.1% life span of the last 10% of the survivors and by 24.1% maximum life span in comparison with the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
From the age of 3 months until their natural deaths, female Swiss-derived SHR mice were subcutaneously injected 5 consecutive days every month with 0.1 ml of normal saline (control) or with 2.5 microg/mouse (approximately 100 microg/kg) of delta-sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-…
Summary · context
There were 54 mice in each group.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1278241605
02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In female SHR mice, Deltaran increased the life span of the last 10% of survivors by 17.1% compared with the control group.
In plain wordsIn mice, Deltaran lengthened the life of the longest-living tenth of animals compared with controls.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseLife span of the last 10% of survivors
Study
mousen = 108
Female Swiss-derived SHR mice, treated for life
Comparator
Saline control
Outcome group
Mortality · Aging and longevity
Measurements
Increase in life span of last 10% of survivors
17.1%
Deltaran vs control
Source sentences
Summary
it increased by 17.1% life span of the last 10% of the survivors
2 context sentences(design, population, supporting numbers)
Summary · context
From the age of 3 months until their natural deaths, female Swiss-derived SHR mice were subcutaneously injected 5 consecutive days every month with 0.1 ml of normal saline (control) or with 2.5 microg/mouse (approximately 100 microg/kg) of delta-sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-…
Summary · context
There were 54 mice in each group.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1278241606
03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In female SHR mice, Deltaran increased maximum life span by 24.1% compared with the control group.
In plain wordsIn mice, Deltaran lengthened the longest life span compared with controls.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseMaximum life span
Study
mousen = 108
Female Swiss-derived SHR mice, treated for life
Comparator
Saline control
Outcome group
Mortality · Aging and longevity
Measurements
Increase in maximum life span
24.1%
Deltaran vs control
Source sentences
Summary
by 24.1% maximum life span in comparison with the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
From the age of 3 months until their natural deaths, female Swiss-derived SHR mice were subcutaneously injected 5 consecutive days every month with 0.1 ml of normal saline (control) or with 2.5 microg/mouse (approximately 100 microg/kg) of delta-sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-…
Summary · context
There were 54 mice in each group.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1278241607
04AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In female SHR mice, Deltaran significantly decreased total spontaneous tumor incidence by 2.6-fold compared with the control group, mainly mammary carcinomas and leukemias.
In plain wordsIn mice, Deltaran lowered the number of spontaneous tumors compared with controls, mainly breast tumors and leukemias.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseTotal spontaneous tumor incidence
Study
mousen = 108
Female Swiss-derived SHR mice, treated for life
Comparator
Saline control
Outcome group
Tumor growth · Cancer
Measurements
Reduction in tumor incidence (fold)
2.6 fold
Deltaran vs control
Source sentences
Summary
We also found that treatment with Deltaran significantly decreased total spontaneous tumor incidence (by 2.6-fold), mainly mammary carcinomas and leukemias in mice as compared with the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
From the age of 3 months until their natural deaths, female Swiss-derived SHR mice were subcutaneously injected 5 consecutive days every month with 0.1 ml of normal saline (control) or with 2.5 microg/mouse (approximately 100 microg/kg) of delta-sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-…
Summary · context
There were 54 mice in each group.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1278241608
05AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In female SHR mice, Deltaran did not influence food consumption.
In plain wordsIn mice, Deltaran did not change how much they ate.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeFood consumption
Study
mousen: not reported in source
Female Swiss-derived SHR mice, treated for life
Comparator
Saline control
Outcome group
Appetite and food intake · Metabolic and weight
Source sentences
Summary
the treatment with Deltaran did not influence food consumption
2 context sentences(design, population, supporting numbers)
Summary · context
From the age of 3 months until their natural deaths, female Swiss-derived SHR mice were subcutaneously injected 5 consecutive days every month with 0.1 ml of normal saline (control) or with 2.5 microg/mouse (approximately 100 microg/kg) of delta-sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-…
Summary · context
There were 54 mice in each group.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1278241601
06AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In female SHR mice, Deltaran decreased body weight.
In plain wordsIn mice, Deltaran lowered body weight.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseBody weight
Study
mousen: not reported in source
Female Swiss-derived SHR mice, treated for life
Comparator
Saline control
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
but decreased the body weight of mice
2 context sentences(design, population, supporting numbers)
Summary · context
From the age of 3 months until their natural deaths, female Swiss-derived SHR mice were subcutaneously injected 5 consecutive days every month with 0.1 ml of normal saline (control) or with 2.5 microg/mouse (approximately 100 microg/kg) of delta-sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-…
Summary · context
There were 54 mice in each group.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1278241602
07AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In female SHR mice, Deltaran slowed the age-related switching-off of estrous function.
In plain wordsIn mice, Deltaran slowed the age-related loss of the estrous cycle.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseAge-related switching-off of estrous function
Study
mousen: not reported in source
Female Swiss-derived SHR mice, treated for life
Comparator
Saline control
Outcome group
Sex hormones and fertility · Aging and longevity
Source sentences
Summary
it slowed down the age-related switching-off of estrous function
2 context sentences(design, population, supporting numbers)
Summary · context
From the age of 3 months until their natural deaths, female Swiss-derived SHR mice were subcutaneously injected 5 consecutive days every month with 0.1 ml of normal saline (control) or with 2.5 microg/mouse (approximately 100 microg/kg) of delta-sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-…
Summary · context
There were 54 mice in each group.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1278241603
08AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In female SHR mice, Deltaran decreased the frequency of chromosome aberrations in bone marrow cells by 22.6%.
In plain wordsIn mice, Deltaran lowered the number of chromosome changes in bone marrow cells.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseChromosome aberrations in bone marrow cells
Study
mousen: not reported in source
Female Swiss-derived SHR mice, treated for life
Comparator
Saline control
Outcome group
Aging markers · Aging and longevity
Measurements
Reduction in chromosome aberration frequency
22.6%
Deltaran vs control
Source sentences
Summary
it decreased by 22.6% the frequency of chromosome aberrations in bone marrow cells
2 context sentences(design, population, supporting numbers)
Summary · context
From the age of 3 months until their natural deaths, female Swiss-derived SHR mice were subcutaneously injected 5 consecutive days every month with 0.1 ml of normal saline (control) or with 2.5 microg/mouse (approximately 100 microg/kg) of delta-sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-…
Summary · context
There were 54 mice in each group.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1278241604

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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