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Study · Not a test of the peptide alone · 2003

3 results

Vasopressin differentially modulates non-NMDA receptors in vasopressin and oxytocin neurons in the supraoptic nucleus.

Hirasawa M, Mouginot D, Kozoriz MG, Kombian SB, Pittman QJ

The Journal of neuroscience : the official journal of the Society for Neuroscience1 May 2003Cited by 52 (Europe PMC)

PMID12764115 (opens in a new tab)PMCIDPMC6741118 (opens in a new tab)DOI10.1523/jneurosci.23-10-04270.2003 (opens in a new tab)PepBankPUB-12764115
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In supraoptic nucleus slices, vasopressin increased evoked EPSCs in oxytocin neurons, while it decreased them in vasopressin neurons.

    In plain wordsIn lab tests on brain cells, vasopressin raised nerve signals in oxytocin-producing cells.

    Peptide
    Oxytocin
    Outcome
    IncreaseEvoked EPSCs in oxytocin neurons after vasopressin
    Study

    n: not reported in source

    supraoptic nucleus neurons, whole-cell electrophysiology with post hoc immunohistochemistry
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    we found that vasopressin decreased evoked EPSCs in vasopressin neurons while increasing EPSCs in oxytocin neurons.
    2 context sentences
    Summary · context
    Presumably by electroporation through perforated patch, we were able to successfully introduce biocytin into cells in which we performed an electrophysiological study.
    Summary · context
    This method enabled us to determine that roughly half of the recorded neurons were immunoreactive to oxytocin-associated neurophysin and showed two characteristic features: an inward rectification and a sustained outward rectification.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In oxytocin neurons, AMPA-induced currents were facilitated by vasopressin, whereas the V1a receptor agonist F-180 had no effect.

    In plain wordsIn lab tests on brain cells, vasopressin boosted AMPA-induced currents in oxytocin-producing cells; a V1a receptor agonist did not.

    Peptide
    Oxytocin
    Outcome
    IncreaseAMPA-induced currents in oxytocin neurons
    Study

    n: not reported in source

    supraoptic nucleus neurons, whole-cell electrophysiology with post hoc immunohistochemistry
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In oxytocin neurons, AMPA-induced currents were facilitated by vasopressin, whereas F-180 had no effect.
    2 context sentences
    Summary · context
    Presumably by electroporation through perforated patch, we were able to successfully introduce biocytin into cells in which we performed an electrophysiological study.
    Summary · context
    This method enabled us to determine that roughly half of the recorded neurons were immunoreactive to oxytocin-associated neurophysin and showed two characteristic features: an inward rectification and a sustained outward rectification.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    An oxytocin receptor antagonist blocked the facilitatory effect of vasopressin in oxytocin neurons.

    In plain wordsIn lab tests on brain cells, blocking the oxytocin receptor stopped vasopressin from boosting nerve signals in oxytocin-producing cells.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin receptor antagonist and the vasopressin facilitation
    Study

    n: not reported in source

    supraoptic nucleus neurons, whole-cell electrophysiology with post hoc immunohistochemistry
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    An oxytocin receptor antagonist blocked the facilitatory effect of vasopressin.
    2 context sentences
    Summary · context
    Presumably by electroporation through perforated patch, we were able to successfully introduce biocytin into cells in which we performed an electrophysiological study.
    Summary · context
    This method enabled us to determine that roughly half of the recorded neurons were immunoreactive to oxytocin-associated neurophysin and showed two characteristic features: an inward rectification and a sustained outward rectification.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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