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Study · Animal study (in vivo) · rat · 2003

4 results

Systemic oxytocin treatment modulates glucocorticoid and mineralocorticoid receptor mRNA in the rat hippocampus.

Petersson M, Uvnäs-Moberg K

Neuroscience letters1 Jun 2003Cited by 36 (Europe PMC)

PMID12759173 (opens in a new tab)DOI10.1016/s0304-3940(03)00334-3 (opens in a new tab)PepBankPUB-12759173
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In male Sprague-Dawley rats, oxytocin treatment decreased glucocorticoid receptor mRNA expression in hippocampal CA1+2.

    In plain wordsIn rats, oxytocin treatment lowered glucocorticoid receptor gene activity in part of the hippocampus.

    Peptide
    Oxytocin
    Outcome
    DecreaseGR mRNA in hippocampal CA1+2
    Study

    ratn: not reported in source

    male Sprague-Dawley rats, dorsal hippocampus
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg once a day · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    The oxytocin treatment decreased GR mRNA expression in CA1+2 and the dentate gyrus (P<0.05), tended to decrease GR mRNA expression in CA3 (P=0.07), and increased MR mRNA expression in the dentate gyrus (P<0.05).
    2 context sentences
    Summary · context
    Oxytocin (1 mg/kg s.c.) was administered once a day for 5 days to male Sprague-Dawley rats.
    Summary · context
    The animals were sacrificed 1 day after treatment and expression of glucocorticoid and mineralocorticoid receptor (GR and MR) mRNA in the dorsal hippocampus was measured with in situ hybridization.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male Sprague-Dawley rats, oxytocin treatment decreased glucocorticoid receptor mRNA expression in the dentate gyrus.

    In plain wordsIn rats, oxytocin treatment lowered glucocorticoid receptor gene activity in the dentate gyrus.

    Peptide
    Oxytocin
    Outcome
    DecreaseGR mRNA in dentate gyrus
    Study

    ratn: not reported in source

    male Sprague-Dawley rats, dorsal hippocampus
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg once a day · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    The oxytocin treatment decreased GR mRNA expression in CA1+2 and the dentate gyrus (P<0.05), tended to decrease GR mRNA expression in CA3 (P=0.07), and increased MR mRNA expression in the dentate gyrus (P<0.05).
    2 context sentences
    Summary · context
    Oxytocin (1 mg/kg s.c.) was administered once a day for 5 days to male Sprague-Dawley rats.
    Summary · context
    The animals were sacrificed 1 day after treatment and expression of glucocorticoid and mineralocorticoid receptor (GR and MR) mRNA in the dorsal hippocampus was measured with in situ hybridization.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In male Sprague-Dawley rats, oxytocin treatment tended to decrease glucocorticoid receptor mRNA in CA3, a change that was not significant.

    In plain wordsIn rats, oxytocin treatment did not clearly change glucocorticoid receptor gene activity in the CA3 region.

    Peptide
    Oxytocin
    Outcome
    No significant changeGR mRNA in CA3
    Study

    ratn: not reported in source

    male Sprague-Dawley rats, dorsal hippocampus
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg once a day · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    The oxytocin treatment decreased GR mRNA expression in CA1+2 and the dentate gyrus (P<0.05), tended to decrease GR mRNA expression in CA3 (P=0.07), and increased MR mRNA expression in the dentate gyrus (P<0.05).
    2 context sentences
    Summary · context
    Oxytocin (1 mg/kg s.c.) was administered once a day for 5 days to male Sprague-Dawley rats.
    Summary · context
    The animals were sacrificed 1 day after treatment and expression of glucocorticoid and mineralocorticoid receptor (GR and MR) mRNA in the dorsal hippocampus was measured with in situ hybridization.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In male Sprague-Dawley rats, oxytocin treatment increased mineralocorticoid receptor mRNA expression in the dentate gyrus.

    In plain wordsIn rats, oxytocin treatment raised mineralocorticoid receptor gene activity in the dentate gyrus.

    Peptide
    Oxytocin
    Outcome
    IncreaseMR mRNA in dentate gyrus
    Study

    ratn: not reported in source

    male Sprague-Dawley rats, dorsal hippocampus
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg once a day · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    The oxytocin treatment decreased GR mRNA expression in CA1+2 and the dentate gyrus (P<0.05), tended to decrease GR mRNA expression in CA3 (P=0.07), and increased MR mRNA expression in the dentate gyrus (P<0.05).
    2 context sentences
    Summary · context
    Oxytocin (1 mg/kg s.c.) was administered once a day for 5 days to male Sprague-Dawley rats.
    Summary · context
    The animals were sacrificed 1 day after treatment and expression of glucocorticoid and mineralocorticoid receptor (GR and MR) mRNA in the dorsal hippocampus was measured with in situ hybridization.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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