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Study · Animal study (in vivo) · goldfish · 2003

2 results

Molecular cloning, pharmacological characterization, and brain mapping of the melanocortin 4 receptor in the goldfish: involvement in the control of food intake.

Cerdá-Reverter JM, Ringholm A, Schiöth HB, Peter RE

Endocrinology1 Jun 2003Cited by 142 (Europe PMC)

PMID12746294 (opens in a new tab)DOI10.1210/en.2002-0213 (opens in a new tab)PepBankPUB-12746294
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In 24-h fasted goldfish, intracerebroventricular MTII inhibited food intake in a dose-dependent manner.

    In plain wordsIn goldfish, MTII injected into the brain reduced food intake after fasting, and a higher dose reduced it more.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake in 24-h fasted goldfish
    Study

    goldfishn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (goldfish).

    Source sentences

    Summary
    Intracerebroventricular MTII administration inhibited food intake in 24-h fasted animals in a dose-dependent manner
  2. 02LabOther designActivity measurement

    In pharmacological profiling of goldfish melanocortin 4 receptor (gMC4R), MTII was identified as a high-affinity agonist analog.

    In plain wordsIn lab tests on goldfish MC4R, MTII was found to be a high-affinity agonist.

    Peptide
    Melanotan II
    Outcome
    Not applicableMTII affinity at goldfish MC4R
    Study

    goldfishn: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas MTII and HS024 were identified as high-affinity agonist and antagonist analogs, respectively.
    1 context sentence
    Summary · context
    Pharmacological profiling showed similar affinities and potency order

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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