Effect of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide on pancreatic, hepatic and duodenal mucosal bicarbonate secretion in the pig.

Glad H, Ainsworth MA, Svendsen P, Fahrenkrug J, Schaffalitzky de Muckadell OB

Digestion1 Jan 2003Cited by 16 (Europe PMC)

PMID12743442DOI10.1159/000069707PepBankPUB-12743442

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Pharmacokinetics
In anaesthetized pigs, VIP infusion raised portal plasma VIP concentrations from 9 pM to 102, 220, 600, 850 and 3,795 pM at increasing doses.
In plain wordsIn pigs, VIP infusion raised VIP levels in the portal blood in step with the dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePortal plasma VIP concentration
Study
pign: not reported in source
anaesthetized pigs
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
250-6,000 pmol/kg x h · infusionAs given in this study (pig).
Measurements
Portal plasma VIP
9 pM
baseline
Portal plasma VIP
102 pM
250 pmol/kg x h
Source sentences
Summary
Infusion of VIP in these concentrations increased the portal plasma concentrations of VIP from 9 to 102, 220, 600, 850 and 3,795 pM, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The potency of pituitary adenylate cyclase-activating polypeptide (PACAP) and the related vasoactive intestinal peptide (VIP) on pancreaticobiliary and duodenal mucosal bicarbonate secretion (DMBS) was studied in anaesthetized pigs.
Report a problemFND-1274344201
02AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized pigs, VIP at 1,000 and 6,000 pmol/kg.h significantly stimulated pancreatic bicarbonate secretion.
In plain wordsIn pigs, VIP infusion raised bicarbonate output from the pancreas.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePancreatic bicarbonate secretion
Study
pign: not reported in source
anaesthetized pigs
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
250-6,000 pmol/kg x h · infusionAs given in this study (pig).
Measurements
Pancreatic bicarbonate secretion
7.6 mmol/h
6,000 pmol/kg.h
Source sentences
Summary
At doses of 1,000 and 6,000 pmol/kg.h all three peptides significantly stimulated pancreatic bicarbonate secretion, VIP from 0.0 to 0.3 and 7.6 mmol/h, PACAP27 from 0.0 to 2.3 and 8.2 mmol/h, and PACAP38 from 0.0 to 0.2 and 7.4 mmol/h, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The potency of pituitary adenylate cyclase-activating polypeptide (PACAP) and the related vasoactive intestinal peptide (VIP) on pancreaticobiliary and duodenal mucosal bicarbonate secretion (DMBS) was studied in anaesthetized pigs.
Report a problemFND-1274344202
03AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized pigs, VIP increased hepatic bicarbonate output only at the highest dose, 6,000 pmol/kg.h.
In plain wordsIn pigs, VIP raised bicarbonate output from the liver only at the highest dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseHepatic bicarbonate output
Study
pign: not reported in source
anaesthetized pigs
Outcome group
Gastrointestinal function · Liver
Studied dose
6,000 pmol/kg x h · infusionAs given in this study (pig).
Measurements
Hepatic bicarbonate output
3.8 mmol/h
6,000 pmol/kg.h
Source sentences
Summary
Only during infusion of 6,000 pmol/kg.h did the three peptides elicit a significant increase in hepatic bicarbonate output. At this dose VIP increased hepatic bicarbonate output from 0.4 to 3.8 mmol/h, PACAP27 from 0.3 to 3.6 mmol/h, and PACAP38 from 0.1 to 1.4 mmol/h, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The potency of pituitary adenylate cyclase-activating polypeptide (PACAP) and the related vasoactive intestinal peptide (VIP) on pancreaticobiliary and duodenal mucosal bicarbonate secretion (DMBS) was studied in anaesthetized pigs.
Report a problemFND-1274344203
04AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized pigs, VIP dose-dependently and significantly increased duodenal mucosal bicarbonate secretion.
In plain wordsIn pigs, VIP raised bicarbonate secretion from the duodenal lining in step with the dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseDuodenal mucosal bicarbonate secretion
Study
pign: not reported in source
anaesthetized pigs
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
500-6,000 pmol/kg x h · infusionAs given in this study (pig).
Measurements
Duodenal mucosal bicarbonate secretion
0.53 mmol/h
6,000 pmol/kg.h
Source sentences
Summary
Infusion of VIP (500, 1,000, 2,000 and 6,000 pmol/kg.h) dose-dependently and significantly enlarged DMBS from 0.09 to 0.19, 0.41, 0.54 and 0.53 mmol/h, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The potency of pituitary adenylate cyclase-activating polypeptide (PACAP) and the related vasoactive intestinal peptide (VIP) on pancreaticobiliary and duodenal mucosal bicarbonate secretion (DMBS) was studied in anaesthetized pigs.
Report a problemFND-1274344204
05AnimalAnimal study (in vivo)Efficacy outcome
In anaesthetized pigs at 6,000 pmol/kg.h, VIP-induced duodenal bicarbonate secretion was 4-fold higher than with PACAP27 and 8-fold higher than with PACAP38.
In plain wordsIn pigs, VIP raised duodenal bicarbonate output more than the related peptides PACAP27 and PACAP38 did at the same dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseDuodenal bicarbonate secretion versus PACAP
Study
pign: not reported in source
anaesthetized pigs
Comparator
PACAP27, PACAP38
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
6,000 pmol/kg x h · infusionAs given in this study (pig).
Source sentences
Summary
A significant effect of PACAP27 and PACAP38 on DMBS was only obtained at a dose of 6,000 pmol/kg.h, and at this dose VIP-induced DMBS was 4- and 8-fold higher than that induced by PACAP27 and PACAP38, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The potency of pituitary adenylate cyclase-activating polypeptide (PACAP) and the related vasoactive intestinal peptide (VIP) on pancreaticobiliary and duodenal mucosal bicarbonate secretion (DMBS) was studied in anaesthetized pigs.
Report a problemFND-1274344205

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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