Effects of medical or surgical castration on erectile function in an animal model.

Traish AM, Munarriz R, O'Connell L, Choi S, Kim SW, Kim NN, Huang YH, Goldstein I

Journal of andrology1 May 2003Cited by 105 (Europe PMC)

PMID12721214DOI10.1002/j.1939-4640.2003.tb02686.xPepBankPUB-12721214

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In male rabbits, plasma testosterone after 2 weeks of leuprolide was 57.4% of intact control levels.
In plain wordsIn male rabbits, testosterone after 2 weeks of leuprolide was 57.4% of intact control levels.
Peptide
Leuprolide
Outcome
DecreasePlasma testosterone at 2 weeks
Study
rabbitn: not reported in source
New Zealand White male rabbits
Comparator
Intact controls
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
107 microg/kg/mo · 2 weeksAs given in this study (rabbit).
Measurements
Testosterone relative to control
57.4%
2 weeks
Source sentences
Summary
At 2 weeks, plasma testosterone levels of orchiectomized and leuprolide acetate-treated animals were 12.8% and 57.4% of intact control animals, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
New Zealand White male rabbits were either kept intact (control); surgically orchiectomized; or treated for 2, 4, or 8 weeks with the LH-RH agonist leuprolide acetate (107 microg/kg/mo).
Report a problemFND-1272121401
02AnimalAnimal study (in vivo)Efficacy outcome
In male rabbits, leuprolide reduced intracavernosal pressure at all tested pelvic nerve stimulation frequencies compared with intact controls.
In plain wordsIn male rabbits, leuprolide reduced penile blood pressure during nerve stimulation compared with intact controls.
Peptide
Leuprolide
Outcome
DecreaseIntracavernosal blood pressure
Study
rabbitn: not reported in source
New Zealand White male rabbits
Comparator
Intact controls
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
107 microg/kg/moAs given in this study (rabbit).
Source sentences
Summary
Androgen deprivation by surgical (orchiectomy) or medical (leuprolide acetate) castration reduced ICP at all frequencies tested but did not alter SAP.
2 context sentences(design, population, supporting numbers)
Summary · context
Erectile function was assessed by continuously recording systemic arterial pressure (SAP) and intracavernosal blood pressure (ICP) and determining the ICP:SAP ratios in response to electrical stimulation of the pelvic nerve at varying frequencies (2.5-32 Hz).
Summary · context
New Zealand White male rabbits were either kept intact (control); surgically orchiectomized; or treated for 2, 4, or 8 weeks with the LH-RH agonist leuprolide acetate (107 microg/kg/mo).
Report a problemFND-1272121402
03AnimalAnimal study (in vivo)Activity measurement
In male rabbits, leuprolide did not alter systemic arterial pressure compared with intact controls.
In plain wordsIn male rabbits, leuprolide did not change systemic arterial pressure compared with intact controls.
Peptide
Leuprolide
Outcome
No significant changeSystemic arterial pressure
Study
rabbitn: not reported in source
New Zealand White male rabbits
Comparator
Intact controls
Outcome group
Blood pressure · Cardiovascular
Studied dose
107 microg/kg/moAs given in this study (rabbit).
Source sentences
Summary
Androgen deprivation by surgical (orchiectomy) or medical (leuprolide acetate) castration reduced ICP at all frequencies tested but did not alter SAP.
1 context sentence(design, population, supporting numbers)
Summary · context
New Zealand White male rabbits were either kept intact (control); surgically orchiectomized; or treated for 2, 4, or 8 weeks with the LH-RH agonist leuprolide acetate (107 microg/kg/mo).
Report a problemFND-1272121403
04AnimalAnimal study (in vivo)Mechanism
In male rabbits, leuprolide did not significantly alter corpus cavernosum nitric oxide synthase activity compared with intact controls.
In plain wordsIn male rabbits, leuprolide did not significantly change penile nitric oxide synthase activity compared with intact controls.
Peptide
Leuprolide
Outcome
No significant changeCorpus cavernosum nitric oxide synthase activity
Study
rabbitn: not reported in source
New Zealand White male rabbits
Comparator
Intact controls
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
107 microg/kg/moAs given in this study (rabbit).
Source sentences
Summary
Nitric oxide synthase and arginase activities in the corpus cavernosum were not significantly altered by surgical or medical castration.
1 context sentence(design, population, supporting numbers)
Summary · context
New Zealand White male rabbits were either kept intact (control); surgically orchiectomized; or treated for 2, 4, or 8 weeks with the LH-RH agonist leuprolide acetate (107 microg/kg/mo).
Report a problemFND-1272121404
05AnimalAnimal study (in vivo)Mechanism
In male rabbits, leuprolide did not significantly alter corpus cavernosum arginase activity compared with intact controls.
In plain wordsIn male rabbits, leuprolide did not significantly change penile arginase activity compared with intact controls.
Peptide
Leuprolide
Outcome
No significant changeCorpus cavernosum arginase activity
Study
rabbitn: not reported in source
New Zealand White male rabbits
Comparator
Intact controls
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
107 microg/kg/moAs given in this study (rabbit).
Source sentences
Summary
Nitric oxide synthase and arginase activities in the corpus cavernosum were not significantly altered by surgical or medical castration.
1 context sentence(design, population, supporting numbers)
Summary · context
New Zealand White male rabbits were either kept intact (control); surgically orchiectomized; or treated for 2, 4, or 8 weeks with the LH-RH agonist leuprolide acetate (107 microg/kg/mo).
Report a problemFND-1272121405
06AnimalAnimal study (in vivo)Mechanism
In male rabbits, erectile tissue staining showed reduced smooth muscle content after leuprolide-mediated androgen deprivation compared with intact controls.
In plain wordsIn male rabbits, leuprolide-treated erectile tissue had less smooth muscle than intact control tissue.
Peptide
Leuprolide
Outcome
DecreaseErectile tissue smooth muscle content
Study
rabbitn: not reported in source
New Zealand White male rabbits
Comparator
Intact controls
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
107 microg/kg/moAs given in this study (rabbit).
Source sentences
Summary
Further, Masson trichrome staining of erectile tissue from androgen-ablated animals showed a reduction in smooth muscle content.
1 context sentence(design, population, supporting numbers)
Summary · context
New Zealand White male rabbits were either kept intact (control); surgically orchiectomized; or treated for 2, 4, or 8 weeks with the LH-RH agonist leuprolide acetate (107 microg/kg/mo).
Report a problemFND-1272121406

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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