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Study · Measured the body's own peptide · 2003

6 results

Serotonin stimulates hypothalamic mRNA expression and local release of neurohypophysial peptides.

Jørgensen H, Kjaer A, Knigge U, Møller M, Warberg J

Journal of neuroendocrinology1 Jun 2003Cited by 59 (Europe PMC)

PMID12716407 (opens in a new tab)DOI10.1046/j.1365-2826.2003.01032.x (opens in a new tab)PepBankPUB-12716407
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male Wistar rats, 5-hydroxytryptophan with fluoxetine increased oxytocin mRNA expression in the paraventricular nucleus.

    In plain wordsIn rats, a serotonin-boosting treatment raised the body's own oxytocin gene activity in one brain area.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin mRNA in PVN after 5-hydroxytryptophan plus fluoxetine
    Study

    ratn: not reported in source

    male Wistar rats, hypothalamic paraventricular and supraoptic nuclei
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    The 5-HT precursor, 5-hydroxytryptophan, injected in combination with the 5-HT reuptake inhibitor, fluoxetine, increased oxytocin mRNA expression in the PVN, and the concentration of vasopressin and oxytocin in plasma, whereas mRNA in the SON was not affected.
    1 context sentence
    Summary · context
    In male Wistar rats, we investigated the 5-HT receptors involved in the 5-HT-induced increase of mRNA expression of vasopressin and oxytocin in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male Wistar rats, 5-hydroxytryptophan with fluoxetine did not affect oxytocin mRNA in the supraoptic nucleus.

    In plain wordsIn rats, a serotonin-boosting treatment did not change the body's own oxytocin gene activity in the supraoptic nucleus.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin mRNA in SON after 5-hydroxytryptophan plus fluoxetine
    Study

    ratn: not reported in source

    male Wistar rats, hypothalamic paraventricular and supraoptic nuclei
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    The 5-HT precursor, 5-hydroxytryptophan, injected in combination with the 5-HT reuptake inhibitor, fluoxetine, increased oxytocin mRNA expression in the PVN, and the concentration of vasopressin and oxytocin in plasma, whereas mRNA in the SON was not affected.
    1 context sentence
    Summary · context
    In male Wistar rats, we investigated the 5-HT receptors involved in the 5-HT-induced increase of mRNA expression of vasopressin and oxytocin in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male Wistar rats, 5-hydroxytryptophan with fluoxetine increased the plasma concentration of oxytocin.

    In plain wordsIn rats, a serotonin-boosting treatment raised the body's own oxytocin level in blood.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after 5-hydroxytryptophan plus fluoxetine
    Study

    ratn: not reported in source

    male Wistar rats, hypothalamic paraventricular and supraoptic nuclei
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    The 5-HT precursor, 5-hydroxytryptophan, injected in combination with the 5-HT reuptake inhibitor, fluoxetine, increased oxytocin mRNA expression in the PVN, and the concentration of vasopressin and oxytocin in plasma, whereas mRNA in the SON was not affected.
    1 context sentence
    Summary · context
    In male Wistar rats, we investigated the 5-HT receptors involved in the 5-HT-induced increase of mRNA expression of vasopressin and oxytocin in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male Wistar rats, intracerebroventricular agonists of the 5-HT1A, 5-HT1B, 5-HT2A and 5-HT2C receptors increased oxytocin mRNA in the supraoptic and paraventricular nuclei.

    In plain wordsIn rats, drugs that activate serotonin receptors raised the body's own oxytocin gene activity in two brain areas.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin mRNA in SON and PVN after 5-HT receptor agonists
    Study

    ratn: not reported in source

    male Wistar rats, hypothalamic paraventricular and supraoptic nuclei
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Intracerebroventricular infusion of 5-HT agonists selective for the 5-HT1A, 5-HT1B, 5-HT2A and 5-HT2C receptor increased oxytocin mRNA in the SON and PVN.
    1 context sentence
    Summary · context
    In male Wistar rats, we investigated the 5-HT receptors involved in the 5-HT-induced increase of mRNA expression of vasopressin and oxytocin in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male Wistar rats, all the infused 5-HT agonists increased peripheral oxytocin concentration.

    In plain wordsIn rats, all the serotonin-receptor drugs tested raised the body's own oxytocin level in blood.

    Peptide
    Oxytocin
    Outcome
    IncreasePeripheral oxytocin concentration after 5-HT agonists
    Study

    ratn: not reported in source

    male Wistar rats, hypothalamic paraventricular and supraoptic nuclei
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    All the 5-HT agonists infused increased peripheral oxytocin concentration and vasopressin was increased by stimulation of the 5-HT2A, 5-HT2C and 5-HT3 receptor.
    1 context sentence
    Summary · context
    In male Wistar rats, we investigated the 5-HT receptors involved in the 5-HT-induced increase of mRNA expression of vasopressin and oxytocin in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male Wistar rats, immunoneutralization of corticotropin-releasing hormone reduced the plasma oxytocin response to 5-hydroxytryptophan and fluoxetine.

    In plain wordsIn rats, blocking corticotropin-releasing hormone lowered the rise in the body's own oxytocin in blood after a serotonin-boosting treatment.

    Peptide
    Oxytocin
    Outcome
    DecreasePlasma oxytocin response after anti-CRH antiserum
    Study

    ratn: not reported in source

    male Wistar rats, hypothalamic paraventricular and supraoptic nuclei
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    To evaluate the involvement of hypothalamic-pituitary system in the 5-hydroxytryptophan and fluoxetine-induced vasopressin secretion, rats were immunoneutralized with a specific anti-corticotropin-releasing hormone antiserum. This treatment reduced plasma vasopressin and oxytocin responses.
    1 context sentence
    Summary · context
    In male Wistar rats, we investigated the 5-HT receptors involved in the 5-HT-induced increase of mRNA expression of vasopressin and oxytocin in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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