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Study · In vitro (cells) · 2003

2 results

Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform.

Giacconi R, Cipriano C, Muzzioli M, Gasparini N, Orlando F, Mocchegiani E

Mechanisms of ageing and development1 Apr 2003Cited by 14 (Europe PMC)

PMID12714242 (opens in a new tab)DOI10.1016/s0047-6374(03)00011-3 (opens in a new tab)PepBankPUB-12714242
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cell experiments, zinc-bound active thymulin increased NK activity more than T3 alone.

    In plain wordsIn cells, zinc-bound active thymulin increased NK activity more than T3 alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseNK cell activity
    Study

    n: not reported in source

    NK cells in vitro
    Comparator
    T3 alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (4) 'In vitro' experiments display more increments on NK cells activity by adding zinc-bound active thymulin than T3 alone.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In old mice, low zinc bioavailability measured by total-to-active thymulin ratio accompanied altered thyroid turnover and depressed IL-2 versus young and very old mice.

    In plain wordsIn old mice, natural thymulin ratios indicated low zinc availability, linked to altered thyroid turnover and lower IL-2 versus young and very old mice.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedThymulin-based zinc bioavailability ratio
    Study

    mousen: not reported in source

    young, old and very old mice
    Comparator
    young and very old mice
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    (3) Low zinc ion bioavailability (tested by the ratio total thymulin/active thymulin) is coupled with altered thyroid hormone turnover and depressed IL-2 in old mice in comparison with young and very old mice.

    This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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