GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons.

Pelsman A, Hoyo-Vadillo C, Gudasheva TA, Seredenin SB, Ostrovskaya RU, Busciglio J

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience1 May 2003Cited by 45 (Europe PMC)

PMID12711349DOI10.1016/s0736-5748(03)00031-5PepBankPUB-12711349

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In human cortical neurons, GVS-111 dose-dependently increased survival after hydrogen peroxide treatment.
In plain wordsIn cells, GVS-111 increased neuron survival after hydrogen peroxide treatment as the dose increased.
Peptide
Noopept (omberacetam)
Outcome
IncreaseSurvival after hydrogen peroxide
Study
humann: not reported in source
H(2)O(2)-treated normal human cortical neurons
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10nM to 100 microMAs given in this study (human).
Measurements
IC(50)
1.21 microM
hydrogen peroxide neuroprotection
IC(50) uncertainty
0.07 microM
reported +/- value; uncertainty type not stated
Source sentences
Summary
GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM.
1 context sentence(design, population, supporting numbers)
Summary · context
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) designated as GVS-111 (DVD-111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons t…
Report a problemFND-1271134901
02LabIn vitro (cells)Mechanism
In human cortical neurons exposed to hydrogen peroxide or iron sulfate, GVS-111 inhibited intracellular free radical accumulation.
In plain wordsIn cells exposed to hydrogen peroxide or iron sulfate, GVS-111 reduced free radical accumulation.
Peptide
Noopept (omberacetam)
Outcome
DecreaseIntracellular free radical accumulation
Study
humann: not reported in source
H(2)O(2)- or FeSO(4)-treated human cortical neurons
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action.
1 context sentence(design, population, supporting numbers)
Summary · context
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) designated as GVS-111 (DVD-111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons t…
Report a problemFND-1271134902
03LabIn vitro (cells)Mechanism
In human cortical neurons exposed to hydrogen peroxide or iron sulfate, GVS-111 inhibited lipid peroxidation damage.
In plain wordsIn cells exposed to hydrogen peroxide or iron sulfate, GVS-111 reduced damage from lipid oxidation.
Peptide
Noopept (omberacetam)
Outcome
DecreaseLipid peroxidation damage
Study
humann: not reported in source
H(2)O(2)- or FeSO(4)-treated human cortical neurons
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action.
1 context sentence(design, population, supporting numbers)
Summary · context
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) designated as GVS-111 (DVD-111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons t…
Report a problemFND-1271134903
04LabIn vitro (cells)Efficacy outcome
In human cortical neuron cultures, GVS-111 provided significantly greater neuroprotection than Piracetam.
In plain wordsIn cells, GVS-111 protected neurons more than Piracetam.
Peptide
Noopept (omberacetam)
Outcome
IncreaseNeuroprotection versus Piracetam
Study
humann: not reported in source
Human cortical neurons
Comparator
Piracetam
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
GVS-111 exhibited significantly higher neuroprotection compared to the standard cognition enhancer Piracetam, or to the antioxidants Vitamin E, propyl gallate and N-tert-butyl-2-sulpho-phenylnitrone (s-PBN).
1 context sentence(design, population, supporting numbers)
Summary · context
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) designated as GVS-111 (DVD-111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons t…
Report a problemFND-1271134904
05LabIn vitro (cells)Efficacy outcome
In human cortical neuron cultures, GVS-111 provided significantly greater neuroprotection than Vitamin E.
In plain wordsIn cells, GVS-111 protected neurons more than Vitamin E.
Peptide
Noopept (omberacetam)
Outcome
IncreaseNeuroprotection versus Vitamin E
Study
humann: not reported in source
Human cortical neurons
Comparator
Vitamin E
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
GVS-111 exhibited significantly higher neuroprotection compared to the standard cognition enhancer Piracetam, or to the antioxidants Vitamin E, propyl gallate and N-tert-butyl-2-sulpho-phenylnitrone (s-PBN).
1 context sentence(design, population, supporting numbers)
Summary · context
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) designated as GVS-111 (DVD-111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons t…
Report a problemFND-1271134905
06LabIn vitro (cells)Efficacy outcome
In human cortical neuron cultures, GVS-111 provided significantly greater neuroprotection than propyl gallate.
In plain wordsIn cells, GVS-111 protected neurons more than propyl gallate.
Peptide
Noopept (omberacetam)
Outcome
IncreaseNeuroprotection versus propyl gallate
Study
humann: not reported in source
Human cortical neurons
Comparator
Propyl gallate
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
GVS-111 exhibited significantly higher neuroprotection compared to the standard cognition enhancer Piracetam, or to the antioxidants Vitamin E, propyl gallate and N-tert-butyl-2-sulpho-phenylnitrone (s-PBN).
1 context sentence(design, population, supporting numbers)
Summary · context
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) designated as GVS-111 (DVD-111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons t…
Report a problemFND-1271134906
07LabIn vitro (cells)Efficacy outcome
In human cortical neuron cultures, GVS-111 provided significantly greater neuroprotection than s-PBN.
In plain wordsIn cells, GVS-111 protected neurons more than s-PBN.
Peptide
Noopept (omberacetam)
Outcome
IncreaseNeuroprotection versus s-PBN
Study
humann: not reported in source
Human cortical neurons
Comparator
N-tert-butyl-2-sulpho-phenylnitrone (s-PBN)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
GVS-111 exhibited significantly higher neuroprotection compared to the standard cognition enhancer Piracetam, or to the antioxidants Vitamin E, propyl gallate and N-tert-butyl-2-sulpho-phenylnitrone (s-PBN).
1 context sentence(design, population, supporting numbers)
Summary · context
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) designated as GVS-111 (DVD-111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons t…
Report a problemFND-1271134907
08LabIn vitro (cells)Efficacy outcome
In Down's syndrome cortical cultures, chronic GVS-111 treatment significantly reduced degenerative changes.
In plain wordsIn cells with Down's syndrome, chronic GVS-111 treatment reduced degenerative changes.
Peptide
Noopept (omberacetam)
Outcome
DecreaseDegenerative changes in Down's syndrome neurons
Study
humann: not reported in source
Down's syndrome human cortical neurons
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · chronic treatmentAs given in this study (human).
Source sentences
Summary
In DS cortical cultures, chronic treatment with GVS-111 significantly reduced the appearance of degenerative changes and enhanced neuronal survival.
1 context sentence(design, population, supporting numbers)
Summary · context
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) designated as GVS-111 (DVD-111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons t…
Report a problemFND-1271134908
09LabIn vitro (cells)Efficacy outcome
In Down's syndrome cortical cultures, chronic GVS-111 treatment enhanced neuronal survival.
In plain wordsIn cells with Down's syndrome, chronic GVS-111 treatment increased neuron survival.
Peptide
Noopept (omberacetam)
Outcome
IncreaseSurvival of Down's syndrome neurons
Study
humann: not reported in source
Down's syndrome human cortical neurons
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · chronic treatmentAs given in this study (human).
Source sentences
Summary
In DS cortical cultures, chronic treatment with GVS-111 significantly reduced the appearance of degenerative changes and enhanced neuronal survival.
1 context sentence(design, population, supporting numbers)
Summary · context
The neuroprotective activity of a novel N-acylprolyl-containing dipeptide analog of the nootropic 2-oxo-1-pyrrolidine acetamide (Piracetam) designated as GVS-111 (DVD-111/Noopept) was tested in two in vitro models of neuronal degeneration mediated by oxidative stress: normal human cortical neurons t…
Report a problemFND-1271134909

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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