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Study · Not a test of the peptide alone · 2003

2 results

An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior.

Lubin DA, Elliott JC, Black MC, Johns JM

Behavioral neuroscience1 Apr 2003Cited by 103 (Europe PMC)

PMID12708515 (opens in a new tab)PMCIDPMC3109068 (opens in a new tab)DOI10.1037/0735-7044.117.2.195 (opens in a new tab)PepBankPUB-12708515
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other

    In rat dams, an oxytocin antagonist (1,000 ng) infused into the central nucleus of the amygdala increased attacks on intruders compared with buffer.

    In plain wordsIn rats, blocking oxytocin in one brain area made mothers attack intruders more often than buffer did.

    Peptide
    Oxytocin
    Outcome
    IncreaseMaternal aggression toward intruders after oxytocin antagonist
    Study

    ratn: not reported in source

    drug-naive rat dams, central nucleus of the amygdala
    Comparator
    Buffer
    Outcome group
    Social behavior and cognition · Mental health and mood

    Source sentences

    Summary
    Dams infused with 1,000 ng OTA attacked intruders significantly more often than buffer-infused dams.
    1 context sentence
    Summary · context
    In this experiment, drug-naive dams were implanted with bilateral cannulas into the central nucleus of the amygdala (CNA) or control area and infused with 1,000 or 500 ng of an oxytocin antagonist (OTA) or buffer, 4 hr before testing.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other

    In rat dams, an oxytocin antagonist infused into the central nucleus of the amygdala did not affect behaviours other than attacks on intruders.

    In plain wordsIn rats, blocking oxytocin in one brain area did not change other behaviours besides attacks on intruders.

    Peptide
    Oxytocin
    Outcome
    No significant changeOther maternal behaviours after oxytocin antagonist
    Study

    ratn: not reported in source

    drug-naive rat dams, central nucleus of the amygdala
    Comparator
    Buffer
    Outcome group
    Social behavior and cognition · Mental health and mood

    Source sentences

    Summary
    OTA did not affect other behaviors, suggesting that disruption of oxytocin activity in the CNA may be sufficient to selectively alter maternal aggressive behavior.
    1 context sentence
    Summary · context
    In this experiment, drug-naive dams were implanted with bilateral cannulas into the central nucleus of the amygdala (CNA) or control area and infused with 1,000 or 500 ng of an oxytocin antagonist (OTA) or buffer, 4 hr before testing.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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