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Study · Measured the body's own peptide · 2003

3 results

Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys.

Winslow JT, Noble PL, Lyons CK, Sterk SM, Insel TR

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology26 Mar 2003Cited by 224 (Europe PMC)

PMID12700704 (opens in a new tab)DOI10.1038/sj.npp.1300128 (opens in a new tab)PepBankPUB-12700704
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In male rhesus monkeys, cerebrospinal fluid oxytocin was lower in nursery-reared than in mother-reared animals at 18, 24, and 36 months of age.

    In plain wordsIn rhesus monkeys, the body's own oxytocin in spinal fluid was lower in nursery-reared animals than in mother-reared animals.

    Peptide
    Oxytocin
    Outcome
    DecreaseCSF oxytocin by rearing condition
    Study

    rhesus monkeyn: not reported in source

    male mother-reared and nursery-reared rhesus monkeys
    Comparator
    Mother-reared monkeys
    Outcome group
    Endogenous peptide levels · Mental health and mood

    Source sentences

    Summary
    Cerebrospinal fluid oxytocin (CSF OT) in NR monkeys was significantly reduced compared to MR monkeys measured at 18, 24, and 36 months of age.
    1 context sentence
    Summary · context
    Mother-reared (MR) and nursery-reared (NR) male rhesus monkeys exhibit profound and persistent differences in social and emotional behavior.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In male rhesus monkeys, cerebrospinal fluid oxytocin was significantly associated with affiliative social behaviours, including allogrooming and reciprocal intermale mounting, at each age.

    In plain wordsIn rhesus monkeys, higher natural oxytocin levels were linked to more friendly social behaviours such as grooming.

    Peptide
    Oxytocin
    Outcome
    Not applicableAssociation of CSF oxytocin with affiliative behaviours
    Study

    rhesus monkeyn: not reported in source

    male mother-reared and nursery-reared rhesus monkeys
    Outcome group
    Social behavior and cognition · Mental health and mood

    Source sentences

    Summary
    Correlations between OT and individual social behavioral profiles measured across rearing conditions also revealed a significant association between OT and the expression of affiliative social behaviors including allogrooming and reciprocal intermale mounting at each age examined.
    1 context sentence
    Summary · context
    Mother-reared (MR) and nursery-reared (NR) male rhesus monkeys exhibit profound and persistent differences in social and emotional behavior.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In male rhesus monkeys, oxytocin levels did not appear sensitive to the presence of a social companion in either rearing group.

    In plain wordsIn rhesus monkeys, the body's own oxytocin levels did not change with a social companion present, in either group.

    Peptide
    Oxytocin
    Outcome
    No significant changeCSF oxytocin response to a social companion during a stressor
    Study

    rhesus monkeyn: not reported in source

    male mother-reared and nursery-reared rhesus monkeys
    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    but OT levels did not appear to be sensitive to the presence of a social companion in either group.
    1 context sentence
    Summary · context
    Mother-reared (MR) and nursery-reared (NR) male rhesus monkeys exhibit profound and persistent differences in social and emotional behavior.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownNot applicableNCT01039766

The Efficacy of a Single Dose of Intranasal Oxytocin in the Prevention of Post Traumatic Stress Disorder (PTSD)

Sheba Medical Centern = 24Feb 2010 to est. Jun 2011

Stress Disorders, Post-Traumatic

Trial pageClinicalTrials.govUpdated 9 Feb 2010

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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