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Study · Animal study (in vivo) · rat · 2003

4 results

Preferential intestinal delivery of long[Arg3] insulin-like growth factor (LR3IGF-I) over IGF-I in preweaning and adult rats.

Shoubridge CA, Read LC

Endocrinology1 May 2003

PMID12697696 (opens in a new tab)DOI10.1210/en.2002-220643 (opens in a new tab)PepBankPUB-12697696
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In preweaning and adult rats, blood levels of iv-injected radiolabelled LR3IGF-I were lower than those of IGF-I at 5 and 10 minutes.

    In plain wordsIn rats, less of the injected LR3IGF-I stayed in the blood than of IGF-I, in young and adult animals.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseBlood retention of labelled peptide at 5 and 10 min
    Study

    ratn: not reported in source

    Preweaning (day 19) and adult rats
    Comparator
    IGF-I
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2.6 microg/kg · intravenous bolus · single bolusAs given in this study (rat).

    Source sentences

    Summary
    In both age groups, the levels of (125)I-IGF-I retained in the blood at both 5 and 10 min were higher than the levels of (125)I-LR(3)IGF-I, consistent with the slower clearance rate for the native peptide.
    1 context sentence
    Summary · context
    IGF-I or LR(3)IGF-I (2.6 microg/kg) was spiked with corresponding (125)I-labeled peptide (10 x 10(6) cpm) and administered iv as a bolus (n = 5-6/group) with blood and tissue samples collected 5 and 10 min post injection.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, radiolabelled LR3IGF-I levels per gram of gastrointestinal tissue were 37-50% higher than those of IGF-I.

    In plain wordsIn rats, gut tissue held more LR3IGF-I per gram than IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseGastrointestinal tissue level of labelled peptide
    Study

    ratn: not reported in source

    Preweaning (day 19) and adult rats
    Comparator
    IGF-I
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2.6 microg/kg · intravenous bolus · single bolusAs given in this study (rat).

    Measurements

    Tissue level difference versus IGF-I
    37 to 50%
    gastrointestinal tract

    Source sentences

    Summary
    In the gastrointestinal tract, the levels of (125)I-LR(3)IGF-I per gram of tissue were 37-50% higher than (125)I-IGF-I.
    1 context sentence
    Summary · context
    IGF-I or LR(3)IGF-I (2.6 microg/kg) was spiked with corresponding (125)I-labeled peptide (10 x 10(6) cpm) and administered iv as a bolus (n = 5-6/group) with blood and tissue samples collected 5 and 10 min post injection.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, there was little difference between preweaning and adult animals in the relative delivery of LR3IGF-I versus IGF-I to the intestine.

    In plain wordsIn rats, the gut delivery advantage of LR3IGF-I over IGF-I was about the same in young and adult animals.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeRelative intestinal delivery across age
    Study

    ratn: not reported in source

    Preweaning (day 19) and adult rats
    Comparator
    IGF-I
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2.6 microg/kg · intravenous bolus · single bolusAs given in this study (rat).

    Source sentences

    Summary
    Surprisingly, there was little difference in the relative delivery of LR(3)IGF-I to IGF-I to the intestine, across developmental age.
    1 context sentence
    Summary · context
    IGF-I or LR(3)IGF-I (2.6 microg/kg) was spiked with corresponding (125)I-labeled peptide (10 x 10(6) cpm) and administered iv as a bolus (n = 5-6/group) with blood and tissue samples collected 5 and 10 min post injection.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, the ratio of LR3IGF-I to IGF-I in gut tissues was approximately 2:1 in both age groups, despite faster clearance of LR3IGF-I from the circulation.

    In plain wordsIn rats, gut tissue held about twice as much LR3IGF-I as IGF-I in both young and adult animals.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseRatio of LR3IGF-I to IGF-I in gut tissues
    Study

    ratn: not reported in source

    Preweaning (day 19) and adult rats
    Comparator
    IGF-I
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2.6 microg/kg · intravenous bolus · single bolusAs given in this study (rat).

    Source sentences

    Summary
    Although bolus iv-injected LR(3)IGF-I was cleared more rapidly from the circulation than IGF-I and was subsequently delivered to the intestine in higher amounts than the native peptide, the ratio of LR(3)IGF-I to IGF-I in gut tissues was approximately 2:1 in both age groups.
    1 context sentence
    Summary · context
    IGF-I or LR(3)IGF-I (2.6 microg/kg) was spiked with corresponding (125)I-labeled peptide (10 x 10(6) cpm) and administered iv as a bolus (n = 5-6/group) with blood and tissue samples collected 5 and 10 min post injection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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