Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats.

Wu CL, Hung CR, Chang FY, Pau KY, Wang PS

Naunyn-Schmiedeberg's archives of pharmacology26 Feb 2003Cited by 43 (Europe PMC)

PMID12690433DOI10.1007/s00210-003-0690-yPepBankPUB-12690433

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In female rats, oxytocin 0.2-0.8 mg/kg inhibited gastric emptying of a non-nutritive liquid meal.
In plain wordsIn female rats, oxytocin slowed the emptying of the stomach.
Peptide
Oxytocin
Outcome
DecreaseGastric emptying
Study
ratn: not reported in source
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
0.2-0.8 mg/kgAs given in this study (rat).
Source sentences
Summary
After administration of OT (0.2-0.8 mg/kg), gastric emptying and gastrointestinal transit were inhibited, whereas the plasma concentration of CCK was increased in a dose-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of oxytocin (OT) on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in female rats.
Report a problemFND-1269043301
02AnimalAnimal study (in vivo)Efficacy outcome
In female rats, oxytocin 0.2-0.8 mg/kg inhibited gastrointestinal transit.
In plain wordsIn female rats, oxytocin slowed the movement of food through the gut.
Peptide
Oxytocin
Outcome
DecreaseGastrointestinal transit
Study
ratn: not reported in source
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
0.2-0.8 mg/kgAs given in this study (rat).
Source sentences
Summary
After administration of OT (0.2-0.8 mg/kg), gastric emptying and gastrointestinal transit were inhibited, whereas the plasma concentration of CCK was increased in a dose-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of oxytocin (OT) on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in female rats.
Report a problemFND-1269043302
03AnimalAnimal study (in vivo)Mechanism
In female rats, oxytocin 0.2-0.8 mg/kg increased plasma cholecystokinin concentration in a dose-dependent manner.
In plain wordsIn female rats, oxytocin raised blood levels of the gut hormone cholecystokinin, more at higher doses.
Peptide
Oxytocin
Outcome
IncreasePlasma cholecystokinin
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
0.2-0.8 mg/kgAs given in this study (rat).
Source sentences
Summary
After administration of OT (0.2-0.8 mg/kg), gastric emptying and gastrointestinal transit were inhibited, whereas the plasma concentration of CCK was increased in a dose-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of oxytocin (OT) on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in female rats.
Report a problemFND-1269043303
04AnimalAnimal study (in vivo)Mechanism
In female rats, the oxytocin receptor antagonist atosiban attenuated oxytocin-induced inhibition of gastric emptying and gastrointestinal transit.
In plain wordsIn female rats, an oxytocin receptor blocker reduced the slowing of stomach emptying and gut transit caused by oxytocin.
Peptide
Oxytocin
Outcome
Not applicableAtosiban effect on oxytocin-induced inhibition
Study
ratn: not reported in source
Comparator
Oxytocin alone
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
0.2-0.8 mg/kgAs given in this study (rat).
Source sentences
Summary
Atosiban, an oxytocin receptor antagonist, effectively attenuated the OT- induced inhibition of gastric emptying and gastrointestinal transit.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of oxytocin (OT) on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in female rats.
Report a problemFND-1269043304
05AnimalAnimal study (in vivo)Mechanism
In female rats, the CCK1 receptor antagonists devazepide and lorglumide attenuated oxytocin-induced inhibition of gastric emptying and gastrointestinal transit.
In plain wordsIn female rats, CCK1 receptor blockers reduced the slowing of stomach emptying and gut transit caused by oxytocin.
Peptide
Oxytocin
Outcome
Not applicableCCK1 antagonists effect on oxytocin-induced inhibition
Study
ratn: not reported in source
Comparator
Oxytocin alone
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
0.2-0.8 mg/kgAs given in this study (rat).
Source sentences
Summary
The selective CCK(1) receptor antagonists, devazepide and lorglumide, effectively attenuated the OT-induced inhibition of gastric emptying and gastrointestinal transit.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of oxytocin (OT) on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in female rats.
Report a problemFND-1269043305
06AnimalAnimal study (in vivo)Mechanism
In female rats, the CCK2 receptor antagonist L-365, 260 did not alter oxytocin-induced inhibition of gastric emptying and gastrointestinal transit.
In plain wordsIn female rats, a CCK2 receptor blocker did not change the slowing of stomach emptying and gut transit caused by oxytocin.
Peptide
Oxytocin
Outcome
No significant changeCCK2 antagonist effect on oxytocin-induced inhibition
Study
ratn: not reported in source
Comparator
Oxytocin alone
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
0.2-0.8 mg/kgAs given in this study (rat).
Source sentences
Summary
L-365, 260, a selective CCK(2) receptor antagonist, did not alter the OT-induced inhibition of gastric emptying and gastrointestinal transit.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of oxytocin (OT) on gastric emptying, gastrointestinal transit, and plasma levels of cholecystokinin (CCK) were studied in female rats.
Report a problemFND-1269043306

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

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