In mice with Dalton's lymphoma, in vivo thymosin alpha‑1 activated tumor-associated macrophages to produce more nitric oxide, also without LPS.
In plain wordsIn mice with a lymphoma, thymosin alpha‑1 made tumor-linked immune cells produce more nitric oxide.
- Peptide
- Thymosin alpha-1
- Outcome
- IncreaseNitric oxide production by tumor-associated macrophages
- Study
mousen: not reported in source
mice bearing Dalton's lymphoma; tumor-associated macrophages- Outcome group
- Immune response · Immune and inflammation
- Studied dose
- Dose not stated
Source sentences
It was found that in vivo administration of aqueous thymic extract obtained from thymus of normal mice or thyalpha1 could activate the TAM to produce enhanced amount of NO
2 context sentences(design, population, supporting numbers)
This is the first study to show that thyalpha1 can activate TAM directly even in the absence of LPS, and may, therefore, have clinical significance.
The present investigation was conducted to study the effect of thymic peptide: thymosinalpha1 (thyalpha1) on the activation of tumor associated mphi (TAM) obtained from mice bearing a transplantable T cell lymphoma of spontaneous origin designated as Dalton's lymphoma, to produce nitric oxide (NO).