In ovariectomized rats receiving PTH, peri-implant bone volume density remained almost equal to that of sham-operated rats throughout observation.
In plain wordsIn ovariectomized rats receiving PTH, bone density around implants remained almost equal to that in sham-operated rats.
- Peptide
- Teriparatide (PTH 1-34)
- Outcome
- No significant changePeri-implant bone volume density
- Study
ratn: not reported in source
Ovariectomized female Wistar rats with tibial titanium implants- Comparator
- Sham-operated rats
- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- 30 microg/kg three days per week · subcutaneousAs given in this study (rat).
Source sentences
When PTH administration was started 21 days after ovariectomy, the volume density of bone around implants in the PTH group was almost the same as that of the Sham group throughout the entire observation period.
4 context sentences(design, population, supporting numbers)
Twelve-week-old female Wistar rats were divided into 3 groups of 24.
The first group (Sham group) was sham-operated; the second group (OVX group) was ovariectomized only; and the third group (PTH group) was subcutaneously administered 30 microg/kg PTH in the dorsal region 3 days per week starting the fourth week after ovariectomy until the end of the experiment.
Titanium screw implants were placed in the proximal metaphysis of the tibia of all 3 groups at 168 days after surgery.
The animals were killed 7, 14, 28, and 56 days after implantation.