Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia.

Khvatova EM, Samartzev VN, Zagoskin PP, Prudchenko IA, Mikhaleva II

Peptides1 Feb 2003Cited by 15 (Europe PMC)

PMID12668217DOI10.1016/s0196-9781(03)00040-8PepBankPUB-12668217

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats subjected to hypoxia, DSIP pretreatment completely inhibited the hypoxia-induced reduction of mitochondrial respiratory activity.
In plain wordsIn rats exposed to low oxygen, DSIP given beforehand fully prevented the drop in mitochondrial respiration.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseHypoxia-induced reduction of mitochondrial respiratory activity
Study
ratn: not reported in source
Rats subjected to hypoxia
Comparator
Hypoxia without DSIP pretreatment
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
120 microgram/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Pretreatment of rats with DSIP at the dose of 120 microgram/kg (i.p.) prior to their subjection to hypoxia completely inhibited hypoxia-induced reduction of mitochondrial respiratory activity.
1 context sentence(design, population, supporting numbers)
Summary · context
In rats subjected to hypoxia, we detected a significant stress-mediated reduction of V3 and ADP/t values.
Report a problemFND-1266821706
02LabEx vivo tissueMechanism
In isolated rat brain mitochondria, DSIP significantly increased the rate of phosphorylated respiration V3.
In plain wordsIn lab tests on rat brain mitochondria, DSIP increased the rate of energy-producing respiration.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreasePhosphorylated respiration rate V3
Study
ratn: not reported in source
Isolated rat brain mitochondria
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
This peptide significantly increased the rate of phosphorylated respiration V3
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the influence of DSIP and Deltaran((R))-a recently developed product based upon DSIP-on processes of oxidative phosphorylation and ATP production in rat brain mitochondria and rat brain homogenates was studied.
Report a problemFND-1266821701
03LabEx vivo tissueMechanism
In isolated rat brain mitochondria, DSIP left the rate of uncoupled respiration V(DNP) unchanged.
In plain wordsIn lab tests on rat brain mitochondria, DSIP did not change the rate of uncoupled respiration.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeUncoupled respiration rate V(DNP)
Study
ratn: not reported in source
Isolated rat brain mitochondria
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
the rate of uncoupled respiration V(DNP) remaining unchanged.
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the influence of DSIP and Deltaran((R))-a recently developed product based upon DSIP-on processes of oxidative phosphorylation and ATP production in rat brain mitochondria and rat brain homogenates was studied.
Report a problemFND-1266821702
04LabEx vivo tissueMechanism
In isolated rat brain mitochondria, DSIP enhanced the respiratory control ratio RCR.
In plain wordsIn lab tests on rat brain mitochondria, DSIP raised how tightly respiration was linked to energy production.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseRespiratory control ratio (RCR)
Study
ratn: not reported in source
Isolated rat brain mitochondria
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
It enhanced the respiratory control ratio RCR
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the influence of DSIP and Deltaran((R))-a recently developed product based upon DSIP-on processes of oxidative phosphorylation and ATP production in rat brain mitochondria and rat brain homogenates was studied.
Report a problemFND-1266821703
05LabEx vivo tissueMechanism
In isolated rat brain mitochondria, DSIP enhanced the rate of ADP phosphorylation.
In plain wordsIn lab tests on rat brain mitochondria, DSIP increased the rate of ADP phosphorylation, a step in energy production.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseRate of ADP phosphorylation
Study
ratn: not reported in source
Isolated rat brain mitochondria
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
the rate of ADP phosphorylation.
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the influence of DSIP and Deltaran((R))-a recently developed product based upon DSIP-on processes of oxidative phosphorylation and ATP production in rat brain mitochondria and rat brain homogenates was studied.
Report a problemFND-1266821704

Studies that did not test the peptide alone1

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

06LabNot a test of Delta sleep-inducing peptide (DSIP) aloneEx vivo tissueMechanism
In rat brain homogenates, DSIP and Deltaran exhibited the same action.
In plain wordsIn lab tests on rat brain tissue, DSIP and Deltaran acted in the same way.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Direction not reportedOxidative phosphorylation in brain homogenates
Study
ratn: not reported in source
Rat brain homogenates
Outcome group
Mitochondrial function · Nervous system and cognition
Source sentences
Summary
DSIP and Deltaran exhibited the same action in rat brain homogenates.
1 context sentence(design, population, supporting numbers)
Summary · context
In this work, the influence of DSIP and Deltaran((R))-a recently developed product based upon DSIP-on processes of oxidative phosphorylation and ATP production in rat brain mitochondria and rat brain homogenates was studied.
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1266821705

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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