By NMR-based modelling, the essential core appeared as a V shape with two orientations, and some conformers of SHU9119 and MTII shared the orientation of compound 1 and others that of compound 2.
In plain wordsIn lab models, MTII can take two different shapes in its key region, like related compounds.
- Peptide
- Melanotan II
- Outcome
- Not applicableOrientation of the essential core in MTII conformers
- Study
n: not reported in source
NMR and molecular modelling- Outcome group
- Receptor activity and mechanism · Pharmacology
Source sentences
Molecular modeling of these compounds based on their NMR data showed that the essential core appeared as a "V" shape with two different orientations, one for compound 1 and some of the conformers of SHU9119 and MTII, and the other for compound 2 and some other conformers of SHU9119 and MTII.
1 context sentence(design, population, supporting numbers)
Comparison of the structures by NMR and molecular modeling of compounds 1 and 2 vs SHU9119 and MTII indicated that, even though they existed as an average of several conformations in solution, there were distinctions in their structures.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.