Activation of murine bone-marrow derived macrophages in vitro with Thymosin-alpha-1 to tumoricidal state: a comparative study on normal and tumour-bearing hosts.

In murine bone-marrow derived macrophages, thymosin alpha‑1 activated the cells to a tumoricidal state in vitro.

In plain wordsIn mouse immune cells in the lab, thymosin alpha‑1 made the cells able to kill tumor cells.

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In murine bone-marrow derived macrophages, thymosin alpha‑1 was linked to release of nitric oxide in vitro.

In plain wordsIn mouse immune cells in the lab, thymosin alpha‑1 treatment came with release of nitric oxide.

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In murine bone-marrow derived macrophages, thymosin alpha‑1 was linked to release of TNF-alpha in vitro.

In plain wordsIn mouse immune cells in the lab, thymosin alpha‑1 treatment came with release of TNF-alpha.

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In murine bone-marrow derived macrophages, thymosin alpha‑1 was linked to release of IL-1 in vitro.

In plain wordsIn mouse immune cells in the lab, thymosin alpha‑1 treatment came with release of IL-1.

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In murine bone-marrow derived macrophages, thymosin alpha‑1 induced cytotoxicity that depended on dose and time.

In plain wordsIn mouse immune cells in the lab, thymosin alpha‑1 killed tumor cells more with higher doses and longer exposure.

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In murine bone-marrow derived macrophages, thymosin alpha‑1 induced secretion of soluble lytic factors that depended on dose and time.

In plain wordsIn mouse immune cells in the lab, thymosin alpha‑1 raised secretion of cell-killing factors with dose and time.

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After thymosin alpha‑1 activation, macrophages from Dalton's Lymphoma-bearing mice had lower cytolytic activity against DL tumour target cells than macrophages from normal mice.

In plain wordsAfter thymosin alpha‑1 treatment, macrophages from tumor-bearing mice killed tumor cells less well than macrophages from normal mice.

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With thymosin alpha‑1, macrophages from Dalton's Lymphoma-bearing mice released more TNF-alpha than macrophages from normal mice.

In plain wordsWith thymosin alpha‑1, macrophages from tumor-bearing mice released more TNF-alpha than macrophages from normal mice.

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With thymosin alpha‑1, macrophages from Dalton's Lymphoma-bearing mice released more IL-1 than macrophages from normal mice.

In plain wordsWith thymosin alpha‑1, macrophages from tumor-bearing mice released more IL-1 than macrophages from normal mice.

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With thymosin alpha‑1, nitric oxide production was lower in macrophages from Dalton's Lymphoma-bearing mice than in macrophages from normal mice.

In plain wordsWith thymosin alpha‑1, macrophages from tumor-bearing mice made less nitric oxide than macrophages from normal mice.

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With thymosin alpha‑1, iNOS expression was lower in macrophages from Dalton's Lymphoma-bearing mice than in macrophages from normal mice.

In plain wordsWith thymosin alpha‑1, macrophages from tumor-bearing mice showed less iNOS than macrophages from normal mice.

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