Intracerebroventricular injection of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibits feeding in chicks.

Tachibana T, Saito S, Tomonaga S, Takagi T, Saito ES, Boswell T, Boswell T, Furuse M

Neuroscience letters1 Mar 2003Cited by 65 (Europe PMC)

PMID12633888DOI10.1016/s0304-3940(03)00017-xPepBankPUB-12633888

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In chicks, intracerebroventricular VIP significantly inhibited food intake over 4 h at doses from 12 to 188 pmol.
In plain wordsIn chicks, VIP injected into the brain reduced food intake over 4 hours.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseFood intake over 4 h
Study
chickn: not reported in source
in vivo
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
12-188 pmol · intracerebroventricular · 4 hAs given in this study (chick).
Source sentences
Summary
ICV injection of both VIP and PACAP significantly inhibited food intake over 4 h at doses ranging from 12 to 188 pmol.
1 context sentence(design, population, supporting numbers)
Summary · context
We therefore examined the effect of intracerebroventricular (ICV) injections of VIP or PACAP on food intake in chicks.
Report a problemFND-1263388801
02AnimalAnimal study (in vivo)Efficacy outcome
In chicks, VIP at 12 pmol significantly inhibited food intake.
In plain wordsIn chicks, a small VIP dose into the brain reduced food intake.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseFood intake at equimolar 12 pmol dose
Study
chickn: not reported in source
in vivo
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
12 pmol · intracerebroventricularAs given in this study (chick).
Source sentences
Summary
we compared the anorexic effect the glucagon superfamily peptides VIP, PACAP, growth hormone-releasing factor (GRF) and glucagon-like peptide-1 (GLP-1) after ICV injection at an equimolar dose (12 pmol).
2 context sentences(design, population, supporting numbers)
Summary · context
All four peptides significantly inhibited food intake
Summary · context
We therefore examined the effect of intracerebroventricular (ICV) injections of VIP or PACAP on food intake in chicks.
Report a problemFND-1263388802
03AnimalAnimal study (in vivo)Efficacy outcome
In chicks at 12 pmol, the food intake inhibition by VIP was weaker than that by GRF and GLP-1.
In plain wordsIn chicks, VIP cut food intake less than GRF and GLP-1 did at the same dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseAnorexic effect of VIP versus GRF and GLP-1
Study
chickn: not reported in source
in vivo
Comparator
GRF, GLP-1
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
12 pmol · intracerebroventricularAs given in this study (chick).
Source sentences
Summary
although the anorexic effects of VIP and PACAP were weaker than those of GRF and GLP-1.
1 context sentence(design, population, supporting numbers)
Summary · context
We therefore examined the effect of intracerebroventricular (ICV) injections of VIP or PACAP on food intake in chicks.
Report a problemFND-1263388803

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.